tetano
Editor, Senior Moderator
Sci Adv
. 2022 Apr 15;8(15):eabm5016.
doi: 10.1126/sciadv.abm5016. Epub 2022 Apr 15.
One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk
Christine Klein[SUP] 1 [/SUP], Max Borsche[SUP] 1 [/SUP], Alexander Balck[SUP] 1 2 [/SUP], Bandik Föh[SUP] 3 4 [/SUP], Johann Rahmöller[SUP] 3 5 [/SUP], Elke Peters[SUP] 6 [/SUP], Jan Knickmann[SUP] 7 [/SUP], Miranda Lane[SUP] 7 [/SUP], Eva-Juliane Vollstedt[SUP] 1 [/SUP], Susanne A Elsner[SUP] 6 [/SUP], Nadja Käding[SUP] 8 [/SUP], Susanne Hauswaldt[SUP] 8 [/SUP], Tanja Lange[SUP] 9 [/SUP], Jennifer E Hundt[SUP] 10 [/SUP], Selina Lehrian[SUP] 3 [/SUP], Julia Giese[SUP] 3 [/SUP], Alexander Mischnik[SUP] 11 [/SUP], Stefan Niemann[SUP] 12 13 [/SUP], Florian Maurer[SUP] 12 [/SUP], Susanne Homolka[SUP] 12 [/SUP], Laura Paulowski[SUP] 12 [/SUP], Jan Kramer[SUP] 7 14 [/SUP], Christoph Twesten[SUP] 15 [/SUP], Christian Sina[SUP] 3 [/SUP], Gabriele Gillessen-Kaesbach[SUP] 16 [/SUP], Hauke Busch[SUP] 10 [/SUP], Marc Ehlers[SUP] 3 [/SUP], Stefan Taube[SUP] 7 [/SUP], Jan Rupp[SUP] 8 [/SUP], Alexander Katalinic[SUP] 6 [/SUP]
Affiliations
Abstract
With newly rising coronavirus disease 2019 (COVID-19) cases, important data gaps remain on (i) long-term dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates in fixed cohorts (ii) identification of risk factors, and (iii) establishment of effective surveillance strategies. By polymerase chain reaction and antibody testing of 1% of the local population and >90,000 app-based datasets, the present study surveilled a catchment area of 300,000 inhabitants from March 2020 to February 2021. Cohort (56% female; mean age, 45.6 years) retention was 75 to 98%. Increased risk for seropositivity was detected in several high-exposure groups, especially nurses. Unreported infections dropped from 92 to 29% during the study. "Contact to COVID-19-affected" was the strongest risk factor, whereas public transportation, having children in school, or tourism did not affect infection rates. With the first SARS-CoV-2 cohort study, we provide a transferable model for effective surveillance, enabling monitoring of reinfection rates and increased preparedness for future pandemics.
. 2022 Apr 15;8(15):eabm5016.
doi: 10.1126/sciadv.abm5016. Epub 2022 Apr 15.
One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk
Christine Klein[SUP] 1 [/SUP], Max Borsche[SUP] 1 [/SUP], Alexander Balck[SUP] 1 2 [/SUP], Bandik Föh[SUP] 3 4 [/SUP], Johann Rahmöller[SUP] 3 5 [/SUP], Elke Peters[SUP] 6 [/SUP], Jan Knickmann[SUP] 7 [/SUP], Miranda Lane[SUP] 7 [/SUP], Eva-Juliane Vollstedt[SUP] 1 [/SUP], Susanne A Elsner[SUP] 6 [/SUP], Nadja Käding[SUP] 8 [/SUP], Susanne Hauswaldt[SUP] 8 [/SUP], Tanja Lange[SUP] 9 [/SUP], Jennifer E Hundt[SUP] 10 [/SUP], Selina Lehrian[SUP] 3 [/SUP], Julia Giese[SUP] 3 [/SUP], Alexander Mischnik[SUP] 11 [/SUP], Stefan Niemann[SUP] 12 13 [/SUP], Florian Maurer[SUP] 12 [/SUP], Susanne Homolka[SUP] 12 [/SUP], Laura Paulowski[SUP] 12 [/SUP], Jan Kramer[SUP] 7 14 [/SUP], Christoph Twesten[SUP] 15 [/SUP], Christian Sina[SUP] 3 [/SUP], Gabriele Gillessen-Kaesbach[SUP] 16 [/SUP], Hauke Busch[SUP] 10 [/SUP], Marc Ehlers[SUP] 3 [/SUP], Stefan Taube[SUP] 7 [/SUP], Jan Rupp[SUP] 8 [/SUP], Alexander Katalinic[SUP] 6 [/SUP]
Affiliations
- PMID: 35427158
- DOI: 10.1126/sciadv.abm5016
Abstract
With newly rising coronavirus disease 2019 (COVID-19) cases, important data gaps remain on (i) long-term dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates in fixed cohorts (ii) identification of risk factors, and (iii) establishment of effective surveillance strategies. By polymerase chain reaction and antibody testing of 1% of the local population and >90,000 app-based datasets, the present study surveilled a catchment area of 300,000 inhabitants from March 2020 to February 2021. Cohort (56% female; mean age, 45.6 years) retention was 75 to 98%. Increased risk for seropositivity was detected in several high-exposure groups, especially nurses. Unreported infections dropped from 92 to 29% during the study. "Contact to COVID-19-affected" was the strongest risk factor, whereas public transportation, having children in school, or tourism did not affect infection rates. With the first SARS-CoV-2 cohort study, we provide a transferable model for effective surveillance, enabling monitoring of reinfection rates and increased preparedness for future pandemics.