tetano
Editor, Senior Moderator
Sci Rep
. 2023 Nov 14;13(1):19863.
doi: 10.1038/s41598-023-47273-8. A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age
Anna Irene Vedel Sørensen[SUP] #[/SUP][SUP] 1 [/SUP], Lampros Spiliopoulos[SUP] #[/SUP][SUP] 2 [/SUP], Peter Bager[SUP] 2 [/SUP], Nete Munk Nielsen[SUP] 2 3 [/SUP], Jørgen Vinsløv Hansen[SUP] 2 [/SUP], Anders Koch[SUP] 4 5 6 [/SUP], Inger Kristine Meder[SUP] 2 [/SUP], Anders Hviid[SUP] 2 7 [/SUP], Steen Ethelberg[SUP] 4 6 [/SUP]
Affiliations
It is not well-described how the acute symptoms of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ by variant, vaccination, sex and age. A cross-sectional questionnaire study linked to national testing- and registry data was conducted among 148,874 SARS-CoV-2 first time reverse transcription polymerase chain reaction (RT-PCR) test-positive individuals and corresponding date-matched symptomatic test-negative controls. Major SARS-CoV-2 variants (Index/wild type, Alpha, Delta and Omicron) were defined using periods of predominance. Risk differences (RDs) were estimated for each of 21 predefined acute symptoms comparing: (1) test-positive and -negative individuals, by variant period, (2) vaccinated and unvaccinated test-positives, by variant period, (3) individuals tested positive during the Omicron and Delta periods, by vaccination status, and (4) vaccinated Omicron test-positive and -negative individuals, by age and sex. Compared to pre-Omicron, RDs between test-positive and test-negative individuals during the Omicron period were lower for most symptoms. RDs for altered sense of smell (dysosmia) and taste (dysgeusia) were highest for Delta (RD = 50.8 (49.4-52.0) and RD = 54.7 (53.4-56.0), respectively) and lowest for Omicron (RD = 12.8 (12.1-13.5) and RD = 11.8 (11.1-12.4), respectively). Across variants, vaccinated individuals reported fewer symptoms. During Omicron, females and 30-59 year-old participants reported more symptoms.
. 2023 Nov 14;13(1):19863.
doi: 10.1038/s41598-023-47273-8. A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age
Anna Irene Vedel Sørensen[SUP] #[/SUP][SUP] 1 [/SUP], Lampros Spiliopoulos[SUP] #[/SUP][SUP] 2 [/SUP], Peter Bager[SUP] 2 [/SUP], Nete Munk Nielsen[SUP] 2 3 [/SUP], Jørgen Vinsløv Hansen[SUP] 2 [/SUP], Anders Koch[SUP] 4 5 6 [/SUP], Inger Kristine Meder[SUP] 2 [/SUP], Anders Hviid[SUP] 2 7 [/SUP], Steen Ethelberg[SUP] 4 6 [/SUP]
Affiliations
- PMID: 37964010
- DOI: 10.1038/s41598-023-47273-8
It is not well-described how the acute symptoms of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ by variant, vaccination, sex and age. A cross-sectional questionnaire study linked to national testing- and registry data was conducted among 148,874 SARS-CoV-2 first time reverse transcription polymerase chain reaction (RT-PCR) test-positive individuals and corresponding date-matched symptomatic test-negative controls. Major SARS-CoV-2 variants (Index/wild type, Alpha, Delta and Omicron) were defined using periods of predominance. Risk differences (RDs) were estimated for each of 21 predefined acute symptoms comparing: (1) test-positive and -negative individuals, by variant period, (2) vaccinated and unvaccinated test-positives, by variant period, (3) individuals tested positive during the Omicron and Delta periods, by vaccination status, and (4) vaccinated Omicron test-positive and -negative individuals, by age and sex. Compared to pre-Omicron, RDs between test-positive and test-negative individuals during the Omicron period were lower for most symptoms. RDs for altered sense of smell (dysosmia) and taste (dysgeusia) were highest for Delta (RD = 50.8 (49.4-52.0) and RD = 54.7 (53.4-56.0), respectively) and lowest for Omicron (RD = 12.8 (12.1-13.5) and RD = 11.8 (11.1-12.4), respectively). Across variants, vaccinated individuals reported fewer symptoms. During Omicron, females and 30-59 year-old participants reported more symptoms.