tetano
Editor, Senior Moderator
Sci Rep
. 2024 Aug 30;14(1):20148.
doi: 10.1038/s41598-024-68250-9. A large scale study of portable sweat test sensor for accurate, non-invasive and rapid COVID-19 screening based on volatile compound marker detection
Isaya Thaveesangsakulthai[SUP] 1 [/SUP], Kaywalee Chatdarong[SUP] 2 [/SUP], Naraporn Somboonna[SUP] 3 4 5 [/SUP], Nuttapon Pombubpa[SUP] 3 4 [/SUP], Tanapat Palaga[SUP] 3 [/SUP], Sureerat Makmuang[SUP] 6 [/SUP], Kanet Wongravee[SUP] 6 [/SUP], Voravee Hoven[SUP] 1 7 [/SUP], Pakpum Somboon[SUP] 8 [/SUP], Pattama Torvorapanit[SUP] 9 10 [/SUP], Thumnoon Nhujak[SUP] 1 [/SUP], Chadin Kulsing[SUP] 11 12 [/SUP]
Affiliations
This study established a novel infield sensing approach based on detection of the volatile compound markers in skin secretions. This was based on analysis of volatile compounds in axillary sweat samples collected from RT-PCR-proven Coronavirus disease 2019 (COVID-19) positive and negative populations using gas chromatography-mass spectrometry (GC-MS). The analysis proposed the possible markers of the monoaromatic compounds and ethyl hexyl acrylate. A portable photo ionization detector (PID) incorporated with the selective material towards the marker compounds was then developed with the pressurized injection approach. This provided the accuracy of 100% in the research phase (n = 125). The developed approach was then applied for screening of 2207 COVID-19 related cases covering the periods of the Alpha, Beta, Delta and Omicron variants of SARS-CoV-2 infection in Bangkok, Thailand. This offered the sensitivity, specificity and accuracy ranges of 92-99, 93-98 and 95-97%, respectively.
Keywords: COVID-19 screening; Disease diagnosis; Modified PID; Sweat sensor; VOCs.
. 2024 Aug 30;14(1):20148.
doi: 10.1038/s41598-024-68250-9. A large scale study of portable sweat test sensor for accurate, non-invasive and rapid COVID-19 screening based on volatile compound marker detection
Isaya Thaveesangsakulthai[SUP] 1 [/SUP], Kaywalee Chatdarong[SUP] 2 [/SUP], Naraporn Somboonna[SUP] 3 4 5 [/SUP], Nuttapon Pombubpa[SUP] 3 4 [/SUP], Tanapat Palaga[SUP] 3 [/SUP], Sureerat Makmuang[SUP] 6 [/SUP], Kanet Wongravee[SUP] 6 [/SUP], Voravee Hoven[SUP] 1 7 [/SUP], Pakpum Somboon[SUP] 8 [/SUP], Pattama Torvorapanit[SUP] 9 10 [/SUP], Thumnoon Nhujak[SUP] 1 [/SUP], Chadin Kulsing[SUP] 11 12 [/SUP]
Affiliations
- PMID: 39209886
- PMCID: PMC11362290
- DOI: 10.1038/s41598-024-68250-9
This study established a novel infield sensing approach based on detection of the volatile compound markers in skin secretions. This was based on analysis of volatile compounds in axillary sweat samples collected from RT-PCR-proven Coronavirus disease 2019 (COVID-19) positive and negative populations using gas chromatography-mass spectrometry (GC-MS). The analysis proposed the possible markers of the monoaromatic compounds and ethyl hexyl acrylate. A portable photo ionization detector (PID) incorporated with the selective material towards the marker compounds was then developed with the pressurized injection approach. This provided the accuracy of 100% in the research phase (n = 125). The developed approach was then applied for screening of 2207 COVID-19 related cases covering the periods of the Alpha, Beta, Delta and Omicron variants of SARS-CoV-2 infection in Bangkok, Thailand. This offered the sensitivity, specificity and accuracy ranges of 92-99, 93-98 and 95-97%, respectively.
Keywords: COVID-19 screening; Disease diagnosis; Modified PID; Sweat sensor; VOCs.