tetano
Editor, Senior Moderator
Sci Rep
. 2024 Aug 6;14(1):18232.
doi: 10.1038/s41598-024-68162-8. Asymptomatic infection and disappearance of clinical symptoms of COVID-19 infectors in China 2022-2023: a cross-sectional study
Kaige Zhang[SUP] 1 [/SUP], Xiaoying Zhong[SUP] 2 [/SUP], Xiaodan Fan[SUP] 1 [/SUP], Dongdong Yu[SUP] 3 [/SUP], Zhuo Chen[SUP] 1 [/SUP], Chen Zhao[SUP] 4 [/SUP], Xiaoyu Zhang[SUP] 4 [/SUP], Zhiyue Guan[SUP] 1 [/SUP], Xuxu Wei[SUP] 1 [/SUP], Siqi Wan[SUP] 1 [/SUP], Xuecheng Zhang[SUP] 1 [/SUP], Mengzhu Zhao[SUP] 1 [/SUP], Qianqian Dai[SUP] 1 [/SUP], Wenjing Liu[SUP] 1 [/SUP], Qianqian Xu[SUP] 1 [/SUP], Yifan Kong[SUP] 1 [/SUP], Songjie Han[SUP] 1 [/SUP], Hongyuan Lin[SUP] 5 [/SUP], Wenhui Wang[SUP] 5 [/SUP], Huiru Jiang[SUP] 1 [/SUP], Chunling Gu[SUP] 1 [/SUP], Xiaowei Zhang[SUP] 5 [/SUP], Tong Jiang[SUP] 6 [/SUP], Shuling Liu[SUP] 1 [/SUP], Herong Cui[SUP] 1 [/SUP], Xinyu Yang[SUP] 7 [/SUP], Yin Jiang[SUP] 4 [/SUP], Zhao Chen[SUP] 4 [/SUP], Yang Sun[SUP] 1 [/SUP], Liyuan Tao[SUP] 1 8 [/SUP], Rui Zheng[SUP] 1 9 [/SUP], Ruijin Qiu[SUP] 1 10 [/SUP], Liangzhen You[SUP] 11 [/SUP], Hongcai Shang[SUP] 12 [/SUP]
Affiliations
To explore the clinical characteristics of patients infected with SARS-CoV-2 nationwide, especially the effect factors of asymptomatic infection and disappearance of clinical symptoms. A total of 66,448 COVID-19 patients in China who have been diagnosed by nucleic acid test or rapid antigen test were surveyed online (December 24, 2022 to January 16, 2023). Our cross-sectional study used descriptive analyses and binary Logistics regression model to assess the correlation between the clinical characteristics and relative factors, including age, gender, pre-existing conditions, reinfection, vaccination and treatment. A total of 64,515 valid questionnaires were collected. Among included participants, 5969 of which were asymptomatic. The symptoms were mainly upper respiratory symptoms, including dry and itchy throat (64.16%), sore throat (59.95%), hoarseness (57.90%), nasal congestion (53.39%). In binary Logistics regression model, we found that male, no pre-existing conditions, reinfection and vaccination have positive correlations with the appearance of asymptomatic COVID-19 patients. In Cox proportional-hazards regression model, considering all clinical symptoms disappeared in 14 days as outcome, we found that ≤ 60 years old, male, no pre-existing conditions, vaccination and adopted treatment have positive correlations with rapid amelioration of clinical symptoms in COVID-19 patients. The clinical symptoms of the participants were mainly upper respiratory symptoms which were according with the infection of Omicron variant. Factors including age, gender, pre-existing conditions and reinfection could influence the clinical characteristics and prognosis of COVID-19 patients. Importantly, vaccination has positive significance for the prevention and treatment of COVID-19. Lastly, the use of Chinese medicine maybe beneficial to COVID-19 patients, however, reasonable guidance is necessary.
Keywords: COVID-19; Clinical characteristics; Cross-sectional study; Regression model; Related factors.
. 2024 Aug 6;14(1):18232.
doi: 10.1038/s41598-024-68162-8. Asymptomatic infection and disappearance of clinical symptoms of COVID-19 infectors in China 2022-2023: a cross-sectional study
Kaige Zhang[SUP] 1 [/SUP], Xiaoying Zhong[SUP] 2 [/SUP], Xiaodan Fan[SUP] 1 [/SUP], Dongdong Yu[SUP] 3 [/SUP], Zhuo Chen[SUP] 1 [/SUP], Chen Zhao[SUP] 4 [/SUP], Xiaoyu Zhang[SUP] 4 [/SUP], Zhiyue Guan[SUP] 1 [/SUP], Xuxu Wei[SUP] 1 [/SUP], Siqi Wan[SUP] 1 [/SUP], Xuecheng Zhang[SUP] 1 [/SUP], Mengzhu Zhao[SUP] 1 [/SUP], Qianqian Dai[SUP] 1 [/SUP], Wenjing Liu[SUP] 1 [/SUP], Qianqian Xu[SUP] 1 [/SUP], Yifan Kong[SUP] 1 [/SUP], Songjie Han[SUP] 1 [/SUP], Hongyuan Lin[SUP] 5 [/SUP], Wenhui Wang[SUP] 5 [/SUP], Huiru Jiang[SUP] 1 [/SUP], Chunling Gu[SUP] 1 [/SUP], Xiaowei Zhang[SUP] 5 [/SUP], Tong Jiang[SUP] 6 [/SUP], Shuling Liu[SUP] 1 [/SUP], Herong Cui[SUP] 1 [/SUP], Xinyu Yang[SUP] 7 [/SUP], Yin Jiang[SUP] 4 [/SUP], Zhao Chen[SUP] 4 [/SUP], Yang Sun[SUP] 1 [/SUP], Liyuan Tao[SUP] 1 8 [/SUP], Rui Zheng[SUP] 1 9 [/SUP], Ruijin Qiu[SUP] 1 10 [/SUP], Liangzhen You[SUP] 11 [/SUP], Hongcai Shang[SUP] 12 [/SUP]
Affiliations
- PMID: 39107338
- PMCID: PMC11303783
- DOI: 10.1038/s41598-024-68162-8
To explore the clinical characteristics of patients infected with SARS-CoV-2 nationwide, especially the effect factors of asymptomatic infection and disappearance of clinical symptoms. A total of 66,448 COVID-19 patients in China who have been diagnosed by nucleic acid test or rapid antigen test were surveyed online (December 24, 2022 to January 16, 2023). Our cross-sectional study used descriptive analyses and binary Logistics regression model to assess the correlation between the clinical characteristics and relative factors, including age, gender, pre-existing conditions, reinfection, vaccination and treatment. A total of 64,515 valid questionnaires were collected. Among included participants, 5969 of which were asymptomatic. The symptoms were mainly upper respiratory symptoms, including dry and itchy throat (64.16%), sore throat (59.95%), hoarseness (57.90%), nasal congestion (53.39%). In binary Logistics regression model, we found that male, no pre-existing conditions, reinfection and vaccination have positive correlations with the appearance of asymptomatic COVID-19 patients. In Cox proportional-hazards regression model, considering all clinical symptoms disappeared in 14 days as outcome, we found that ≤ 60 years old, male, no pre-existing conditions, vaccination and adopted treatment have positive correlations with rapid amelioration of clinical symptoms in COVID-19 patients. The clinical symptoms of the participants were mainly upper respiratory symptoms which were according with the infection of Omicron variant. Factors including age, gender, pre-existing conditions and reinfection could influence the clinical characteristics and prognosis of COVID-19 patients. Importantly, vaccination has positive significance for the prevention and treatment of COVID-19. Lastly, the use of Chinese medicine maybe beneficial to COVID-19 patients, however, reasonable guidance is necessary.
Keywords: COVID-19; Clinical characteristics; Cross-sectional study; Regression model; Related factors.