tetano
Editor, Senior Moderator
Sci Rep
. 2021 Apr 22;11(1):8731.
doi: 10.1038/s41598-021-87917-1.
Clinical features and disease severity in an Iranian population of inpatients with COVID-19
Shima Nabavi[SUP] 1 [/SUP], Zahra Javidarabshahi[SUP] 2 [/SUP], Abolghasem Allahyari[SUP] 3 [/SUP], Mohammad Ramezani[SUP] 4 [/SUP], Mohsen Seddigh-Shamsi[SUP] 3 [/SUP], Sahar Ravanshad[SUP] 1 [/SUP], Mina AkbariRad[SUP] 1 [/SUP], Farnoosh Ebrahimzadeh[SUP] 1 [/SUP], Shohre Khatami[SUP] 1 [/SUP], Maryam Emadzadeh[SUP] 5 [/SUP], Neda Saeedian[SUP] 1 [/SUP], Ahmadreza Zarifian[SUP] 5 [/SUP], Maryam Miri[SUP] 6 [/SUP], Fariba Rezaeetalab[SUP] 2 [/SUP], Sepide Hejazi[SUP] 2 [/SUP], Reza Basiri[SUP] 2 [/SUP], Mahnaz Mozdourian[SUP] 7 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ? 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O[SUB]2[/SUB] saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO[SUB]2[/SUB], and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O[SUB]2[/SUB] saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O[SUB]2[/SUB] saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO[SUB]2[/SUB] were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients.
. 2021 Apr 22;11(1):8731.
doi: 10.1038/s41598-021-87917-1.
Clinical features and disease severity in an Iranian population of inpatients with COVID-19
Shima Nabavi[SUP] 1 [/SUP], Zahra Javidarabshahi[SUP] 2 [/SUP], Abolghasem Allahyari[SUP] 3 [/SUP], Mohammad Ramezani[SUP] 4 [/SUP], Mohsen Seddigh-Shamsi[SUP] 3 [/SUP], Sahar Ravanshad[SUP] 1 [/SUP], Mina AkbariRad[SUP] 1 [/SUP], Farnoosh Ebrahimzadeh[SUP] 1 [/SUP], Shohre Khatami[SUP] 1 [/SUP], Maryam Emadzadeh[SUP] 5 [/SUP], Neda Saeedian[SUP] 1 [/SUP], Ahmadreza Zarifian[SUP] 5 [/SUP], Maryam Miri[SUP] 6 [/SUP], Fariba Rezaeetalab[SUP] 2 [/SUP], Sepide Hejazi[SUP] 2 [/SUP], Reza Basiri[SUP] 2 [/SUP], Mahnaz Mozdourian[SUP] 7 [/SUP]
Affiliations
- PMID: 33888747
- DOI: 10.1038/s41598-021-87917-1
Abstract
Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ? 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O[SUB]2[/SUB] saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO[SUB]2[/SUB], and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O[SUB]2[/SUB] saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O[SUB]2[/SUB] saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO[SUB]2[/SUB] were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients.