tetano
Editor, Senior Moderator
Sci Rep
. 2023 Dec 20;13(1):22718.
doi: 10.1038/s41598-023-50075-7. Combining blood glucose and SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio facilitates prediction of imminent ventilatory needs in emergency room COVID-19 patients
Kazuya Sakai[SUP] #[/SUP][SUP] 1 [/SUP], Kai Okoda[SUP] #[/SUP][SUP] 2 [/SUP], Mototsugu Nishii[SUP] 3 [/SUP], Ryo Saji[SUP] 1 [/SUP], Fumihiro Ogawa[SUP] 1 [/SUP], Takeru Abe[SUP] 1 [/SUP], Ichiro Takeuchi[SUP] 1 2 [/SUP]
Affiliations
The increasing requirement of mechanical ventilation (MV) due to the novel coronavirus disease (COVID-19) is still a global threat. The aim of this study is to identify markers that can easily stratify the impending use of MV in the emergency room (ER). A total of 106 patients with COVID-19 requiring oxygen support were enrolled. Fifty-nine patients were provided MV 0.5 h (interquartile range: 0.3 to 1.4) post-admission. Clinical and laboratory data before intubation were collected. Using a multivariate logistic regression model, we identified four markers associated with the impending use of MV, including the ratio of peripheral blood oxygen saturation to fraction of inspired oxygen (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio), alanine aminotransferase, blood glucose (BG), and lymphocyte counts. Among these markers, SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio and BG, which can be measured easily and immediately, showed higher accuracy (AUC: 0.88) than SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio alone (AUC: 0.84), despite no significant difference (DeLong test: P = 0.591). Moreover, even in patients without severe respiratory failure (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio > 300), BG (> 138 mg/dL) was predictive of MV use. Measuring BG and SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio may be a simple and versatile new strategy to accurately identify ER patients with COVID-19 at high risk for the imminent need of MV.
. 2023 Dec 20;13(1):22718.
doi: 10.1038/s41598-023-50075-7. Combining blood glucose and SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio facilitates prediction of imminent ventilatory needs in emergency room COVID-19 patients
Kazuya Sakai[SUP] #[/SUP][SUP] 1 [/SUP], Kai Okoda[SUP] #[/SUP][SUP] 2 [/SUP], Mototsugu Nishii[SUP] 3 [/SUP], Ryo Saji[SUP] 1 [/SUP], Fumihiro Ogawa[SUP] 1 [/SUP], Takeru Abe[SUP] 1 [/SUP], Ichiro Takeuchi[SUP] 1 2 [/SUP]
Affiliations
- PMID: 38123659
- DOI: 10.1038/s41598-023-50075-7
The increasing requirement of mechanical ventilation (MV) due to the novel coronavirus disease (COVID-19) is still a global threat. The aim of this study is to identify markers that can easily stratify the impending use of MV in the emergency room (ER). A total of 106 patients with COVID-19 requiring oxygen support were enrolled. Fifty-nine patients were provided MV 0.5 h (interquartile range: 0.3 to 1.4) post-admission. Clinical and laboratory data before intubation were collected. Using a multivariate logistic regression model, we identified four markers associated with the impending use of MV, including the ratio of peripheral blood oxygen saturation to fraction of inspired oxygen (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio), alanine aminotransferase, blood glucose (BG), and lymphocyte counts. Among these markers, SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio and BG, which can be measured easily and immediately, showed higher accuracy (AUC: 0.88) than SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio alone (AUC: 0.84), despite no significant difference (DeLong test: P = 0.591). Moreover, even in patients without severe respiratory failure (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio > 300), BG (> 138 mg/dL) was predictive of MV use. Measuring BG and SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ratio may be a simple and versatile new strategy to accurately identify ER patients with COVID-19 at high risk for the imminent need of MV.