tetano
Editor, Senior Moderator
Sci Rep
. 2024 Mar 20;14(1):6690.
doi: 10.1038/s41598-024-55378-x. Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study
Baptiste Grangier[SUP] 1 [/SUP], Charles-Hervé Vacheron[SUP] 1 2 [/SUP], Donatien De Marignan[SUP] 1 [/SUP], Jean-Sebastien Casalegno[SUP] 3 4 [/SUP], Sandrine Couray-Targe[SUP] 5 [/SUP], Audrey Bestion[SUP] 5 [/SUP], Florence Ader[SUP] 6 7 [/SUP], Jean-Christophe Richard[SUP] 8 9 [/SUP], Emilie Frobert[SUP] 3 4 [/SUP], Laurent Argaud[SUP] 10 [/SUP], Thomas Rimmele[SUP] 11 [/SUP], Anne-Claire Lukaszewicz[SUP] 11 [/SUP], Frédéric Aubrun[SUP] 12 [/SUP], Frédéric Dailler[SUP] 13 [/SUP], Jean-Luc Fellahi[SUP] 14 [/SUP], Julien Bohe[SUP] 1 [/SUP], Vincent Piriou[SUP] 1 15 [/SUP], Bernard Allaouchiche[SUP] 1 16 [/SUP], Arnaud Friggeri[SUP] 1 4 [/SUP], Florent Wallet[SUP] 17 18 [/SUP]; Lyon Sud COVID-19 ICU
Collaborators, Affiliations
This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients. At admission, patients in the COVID-19 group were significantly less severe than the others according to the simplified acute physiology score-2 (SAPS-II) and sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, COVID-19 (sHR = 1.61; 95% CI 1.10; 2.36) and H1N1 (sHR = 1.87; 95% CI 1.20; 2.93) were associated with a statistically significant higher mortality while seasonal influenza was not (sHR = 0.93; 95% CI 0.65; 1.31), when compared to RSV. Despite occurring in more severe patients, RSV and seasonal influenza group appear to be associated with a more favorable outcome than COVID-19 and H1N1 groups.
Keywords: ARDS; CARV; Influenza; RSV; SARS COV 2.
. 2024 Mar 20;14(1):6690.
doi: 10.1038/s41598-024-55378-x. Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study
Baptiste Grangier[SUP] 1 [/SUP], Charles-Hervé Vacheron[SUP] 1 2 [/SUP], Donatien De Marignan[SUP] 1 [/SUP], Jean-Sebastien Casalegno[SUP] 3 4 [/SUP], Sandrine Couray-Targe[SUP] 5 [/SUP], Audrey Bestion[SUP] 5 [/SUP], Florence Ader[SUP] 6 7 [/SUP], Jean-Christophe Richard[SUP] 8 9 [/SUP], Emilie Frobert[SUP] 3 4 [/SUP], Laurent Argaud[SUP] 10 [/SUP], Thomas Rimmele[SUP] 11 [/SUP], Anne-Claire Lukaszewicz[SUP] 11 [/SUP], Frédéric Aubrun[SUP] 12 [/SUP], Frédéric Dailler[SUP] 13 [/SUP], Jean-Luc Fellahi[SUP] 14 [/SUP], Julien Bohe[SUP] 1 [/SUP], Vincent Piriou[SUP] 1 15 [/SUP], Bernard Allaouchiche[SUP] 1 16 [/SUP], Arnaud Friggeri[SUP] 1 4 [/SUP], Florent Wallet[SUP] 17 18 [/SUP]; Lyon Sud COVID-19 ICU
Collaborators, Affiliations
- PMID: 38509095
- DOI: 10.1038/s41598-024-55378-x
This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients. At admission, patients in the COVID-19 group were significantly less severe than the others according to the simplified acute physiology score-2 (SAPS-II) and sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, COVID-19 (sHR = 1.61; 95% CI 1.10; 2.36) and H1N1 (sHR = 1.87; 95% CI 1.20; 2.93) were associated with a statistically significant higher mortality while seasonal influenza was not (sHR = 0.93; 95% CI 0.65; 1.31), when compared to RSV. Despite occurring in more severe patients, RSV and seasonal influenza group appear to be associated with a more favorable outcome than COVID-19 and H1N1 groups.
Keywords: ARDS; CARV; Influenza; RSV; SARS COV 2.