tetano
Editor, Senior Moderator
Sci Rep
. 2024 Oct 7;14(1):23295.
doi: 10.1038/s41598-024-73004-8. COVID-19 mRNA booster vaccination induces robust antibody responses but few adverse events among SARS-CoV-2 naïve nursing home residents
Masae Itamochi[SUP] 1 [/SUP], Shunsuke Yazawa[SUP] 1 [/SUP], Yumiko Saga[SUP] 1 [/SUP], Takahisa Shimada[SUP] 1 [/SUP], Kosuke Tamura[SUP] 2 [/SUP], Emi Maenishi[SUP] 3 [/SUP], Junko Isobe[SUP] 3 [/SUP], Hitoshi Sasajima[SUP] 4 [/SUP], Chikako Kawashiri[SUP] 4 [/SUP], Hideki Tani[SUP] 1 [/SUP], Kazunori Oishi[SUP] 5 [/SUP]
Affiliations
Residents in nursing homes face heightened COVID-19 risks. We aimed to assess the adverse events (AEs) rates and antibody responses after the first to the fifth dose of COVID-19 mRNA vaccination in a nursing home cohort. Ninety-five SARS-CoV-2 naïve participants consisted of 26 staff (median age, 51 years) and 69 residents (median age, 88 years). Life-threatening AEs were reported in neither residents nor staff. The severity of non-life-threatening AEs was graded, and severe AEs were reported only in staff. The AEs rates were considerably lower in residents, compared to those in staff. Anti-RBD IgG and the neutralizing titers (NTs) against Wuhan and Omicron BA.4/BA.5 did not differ significantly between those with 'any AE' and 'no AE' among both staff and residents two months after the second, third and fifth doses, while the anti-RBD IgG significantly differed between two groups after third dose in residents. These findings suggest that the anti-RBD IgG and the NTs increase regardless of the occurrence of AEs. Our study underscores a robust antibody response in both in staff and residents, and fewer AEs following COVID-19 vaccination in SARS-CoV-2 naïve residents than staff, supporting the recommendation for mRNA booster doses in older adults at high-risk care facilities.
Keywords: COVID-19; Life-threatening adverse events; MRNA booster vaccination; Nursing home residents; Omicron variants; SARS-CoV-2.
. 2024 Oct 7;14(1):23295.
doi: 10.1038/s41598-024-73004-8. COVID-19 mRNA booster vaccination induces robust antibody responses but few adverse events among SARS-CoV-2 naïve nursing home residents
Masae Itamochi[SUP] 1 [/SUP], Shunsuke Yazawa[SUP] 1 [/SUP], Yumiko Saga[SUP] 1 [/SUP], Takahisa Shimada[SUP] 1 [/SUP], Kosuke Tamura[SUP] 2 [/SUP], Emi Maenishi[SUP] 3 [/SUP], Junko Isobe[SUP] 3 [/SUP], Hitoshi Sasajima[SUP] 4 [/SUP], Chikako Kawashiri[SUP] 4 [/SUP], Hideki Tani[SUP] 1 [/SUP], Kazunori Oishi[SUP] 5 [/SUP]
Affiliations
- PMID: 39375365
- DOI: 10.1038/s41598-024-73004-8
Residents in nursing homes face heightened COVID-19 risks. We aimed to assess the adverse events (AEs) rates and antibody responses after the first to the fifth dose of COVID-19 mRNA vaccination in a nursing home cohort. Ninety-five SARS-CoV-2 naïve participants consisted of 26 staff (median age, 51 years) and 69 residents (median age, 88 years). Life-threatening AEs were reported in neither residents nor staff. The severity of non-life-threatening AEs was graded, and severe AEs were reported only in staff. The AEs rates were considerably lower in residents, compared to those in staff. Anti-RBD IgG and the neutralizing titers (NTs) against Wuhan and Omicron BA.4/BA.5 did not differ significantly between those with 'any AE' and 'no AE' among both staff and residents two months after the second, third and fifth doses, while the anti-RBD IgG significantly differed between two groups after third dose in residents. These findings suggest that the anti-RBD IgG and the NTs increase regardless of the occurrence of AEs. Our study underscores a robust antibody response in both in staff and residents, and fewer AEs following COVID-19 vaccination in SARS-CoV-2 naïve residents than staff, supporting the recommendation for mRNA booster doses in older adults at high-risk care facilities.
Keywords: COVID-19; Life-threatening adverse events; MRNA booster vaccination; Nursing home residents; Omicron variants; SARS-CoV-2.