tetano
Editor, Senior Moderator
Sci Rep
. 2021 Apr 13;11(1):8021.
doi: 10.1038/s41598-021-87535-x.
Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
Xia Wang[SUP] #[/SUP][SUP] 1 [/SUP], Pu Yang[SUP] #[/SUP][SUP] 1 [/SUP], Junwen Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Pin Liu[SUP] #[/SUP][SUP] 1 [/SUP], Cong Wei[SUP] 1 [/SUP], Juanjuan Guo[SUP] 2 [/SUP], Yuanzhen Zhang[SUP] 2 [/SUP], Dongchi Zhao[SUP] 3 [/SUP]
Affiliations
Abstract
At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.
. 2021 Apr 13;11(1):8021.
doi: 10.1038/s41598-021-87535-x.
Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
Xia Wang[SUP] #[/SUP][SUP] 1 [/SUP], Pu Yang[SUP] #[/SUP][SUP] 1 [/SUP], Junwen Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Pin Liu[SUP] #[/SUP][SUP] 1 [/SUP], Cong Wei[SUP] 1 [/SUP], Juanjuan Guo[SUP] 2 [/SUP], Yuanzhen Zhang[SUP] 2 [/SUP], Dongchi Zhao[SUP] 3 [/SUP]
Affiliations
- PMID: 33850202
- DOI: 10.1038/s41598-021-87535-x
Abstract
At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.