tetano
Editor, Senior Moderator
Sci Rep
. 2024 Dec 28;14(1):31138.
doi: 10.1038/s41598-024-82412-9. Evaluation of vascular photobiomodulation for orofacial pain and tension type headache following COVID 19 in a pragmatic randomized clinical trial
Mayra Costanti Vilela Campos[SUP] 1 [/SUP], Silvana Simões Velloso Schuler[SUP] 1 [/SUP], Ana Julia Lacerda[SUP] 1 [/SUP], Adriana Cátia Mazzoni[SUP] 1 [/SUP], Tamiris Silva[SUP] 1 [/SUP], Francine Cristina Silva Rosa[SUP] 2 [/SUP], Manoela Domingues Martins[SUP] 3 [/SUP], Kristianne Porta Santos Fernandes[SUP] 1 [/SUP], Elsa Susana Fonseca[SUP] 4 [/SUP], Raquel Agnelli Mesquita-Ferrari[SUP] 1 [/SUP], Anna Carolina Ratto Tempestini Horliana[SUP] 1 [/SUP], Sandra Kalil Bussadori[SUP] 1 [/SUP], Lara Jansiski Motta[SUP] 5 [/SUP]
Affiliations
This pragmatic double-blind randomized clinical trial aims to assess the impact of vascular photobiomodulation on post-COVID-19 patients experiencing tension-type headache, orofacial pain, or both persisting for more than 3 months. Participants were divided into two groups: vascular photobiomodulation (VPBM) and simulated VPBM. Their conditions were evaluated using the Brief Pain Inventory (BPI), Visual Analogue Scale, and Headache Impact Test (HIT-6). Data analysis included both inter and intragroup assessments, employing per-protocol and intention-to-treat analyses. Significant differences were observed in pain levels pre- and post-treatment and between the two groups. These differences were evident in the average pain experienced in the previous week (p = 0.010) and various dimensions of the BPI questionnaire, such as the degree of pain interference with walking (p = 0.011), work (p = 0.009), sleep (p = 0.012), and enjoyment of life (p = 0.016). However, there was no statistically significant difference in headache impact on activities of daily living as measured by the HIT. Vascular photobiomodulation shows promise in reducing pain and enhancing the ability to engage in daily activities among post-COVID-19 patients experiencing persistent headaches and orofacial pain.
Keywords: Covid-19; Facial pain; Intention to treat analysis; Photobiomodulation; Quality of life; Tension-type headache.
. 2024 Dec 28;14(1):31138.
doi: 10.1038/s41598-024-82412-9. Evaluation of vascular photobiomodulation for orofacial pain and tension type headache following COVID 19 in a pragmatic randomized clinical trial
Mayra Costanti Vilela Campos[SUP] 1 [/SUP], Silvana Simões Velloso Schuler[SUP] 1 [/SUP], Ana Julia Lacerda[SUP] 1 [/SUP], Adriana Cátia Mazzoni[SUP] 1 [/SUP], Tamiris Silva[SUP] 1 [/SUP], Francine Cristina Silva Rosa[SUP] 2 [/SUP], Manoela Domingues Martins[SUP] 3 [/SUP], Kristianne Porta Santos Fernandes[SUP] 1 [/SUP], Elsa Susana Fonseca[SUP] 4 [/SUP], Raquel Agnelli Mesquita-Ferrari[SUP] 1 [/SUP], Anna Carolina Ratto Tempestini Horliana[SUP] 1 [/SUP], Sandra Kalil Bussadori[SUP] 1 [/SUP], Lara Jansiski Motta[SUP] 5 [/SUP]
Affiliations
- PMID: 39730820
- PMCID: PMC11681234
- DOI: 10.1038/s41598-024-82412-9
This pragmatic double-blind randomized clinical trial aims to assess the impact of vascular photobiomodulation on post-COVID-19 patients experiencing tension-type headache, orofacial pain, or both persisting for more than 3 months. Participants were divided into two groups: vascular photobiomodulation (VPBM) and simulated VPBM. Their conditions were evaluated using the Brief Pain Inventory (BPI), Visual Analogue Scale, and Headache Impact Test (HIT-6). Data analysis included both inter and intragroup assessments, employing per-protocol and intention-to-treat analyses. Significant differences were observed in pain levels pre- and post-treatment and between the two groups. These differences were evident in the average pain experienced in the previous week (p = 0.010) and various dimensions of the BPI questionnaire, such as the degree of pain interference with walking (p = 0.011), work (p = 0.009), sleep (p = 0.012), and enjoyment of life (p = 0.016). However, there was no statistically significant difference in headache impact on activities of daily living as measured by the HIT. Vascular photobiomodulation shows promise in reducing pain and enhancing the ability to engage in daily activities among post-COVID-19 patients experiencing persistent headaches and orofacial pain.
Keywords: Covid-19; Facial pain; Intention to treat analysis; Photobiomodulation; Quality of life; Tension-type headache.