tetano
Editor, Senior Moderator
Sci Rep
. 2024 Sep 5;14(1):20728.
doi: 10.1038/s41598-024-71476-2. Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
Pablo Delgado-Wicke[SUP] #[/SUP][SUP] 1 [/SUP], Sara Fernández de Córdoba-Oñate[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Emilia Roy-Vallejo[SUP] 5 [/SUP], Estíbaliz Alegría-Carrasco[SUP] 1 [/SUP], Diego A Rodríguez-Serrano[SUP] 6 [/SUP], Amalia Lamana[SUP] 7 [/SUP], Nuria Montes[SUP] 2 8 9 [/SUP], Ana Nicolao-Gómez[SUP] 1 [/SUP], Rosa Carracedo-Rodríguez[SUP] 1 [/SUP], Ana Marcos-Jiménez[SUP] 10 [/SUP], Paula Díaz-Fernández[SUP] 10 [/SUP], José M Galván-Román[SUP] 5 [/SUP], Laura Rabes-Rodríguez[SUP] 5 [/SUP], Marta Sanz-Alba[SUP] 5 [/SUP], Jesús Álvarez-Rodríguez[SUP] 5 [/SUP], Almudena Villa-Martí[SUP] 5 [/SUP], Carlos Rodríguez-Franco[SUP] 5 [/SUP], Gonzalo Villapalos-García[SUP] 11 12 [/SUP], Pablo Zubiaur[SUP] 11 12 [/SUP], Francisco Abad-Santos[SUP] 11 12 [/SUP], Ignacio de Los Santos[SUP] 5 13 [/SUP], Rosa P Gomariz[SUP] 7 [/SUP], Rosario García-Vicuña[SUP] 2 14 [/SUP], Cecilia Muñoz-Calleja[SUP] 10 14 13 [/SUP], Isidoro González-Álvaro[SUP] #[/SUP][SUP] 15 [/SUP], Elena Fernández-Ruiz[SUP] #[/SUP][SUP] 16 17 [/SUP]; PREDINMUN-COVID Group
Collaborators, Affiliations
The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (TYK2, STAT1, STAT4, OAS1, SOCS) and the vasoactive intestinal peptide and its receptors (VIP/VIPR1,2) were studied. To analyse the association between polymorphisms and severity, a model adjusted by age, sex and different comorbidities was generated by ordinal logistic regression. The genotypes rs8108236-AA (OR 0.12 [95% CI 0.02-0.53]; p = 0.007) and rs280519-AG (OR 0.74 [95% CI 0.56-0.99]; p = 0.03) in TYK2, and rs688136-CC (OR 0.7 [95% CI 0.5-0.99]; p = 0.046) in VIP, were associated with lower severity; in contrast, rs3853839-GG in TLR7 (OR 1.44 [95% CI 1.07-1.94]; p = 0.016), rs280500-AG (OR 1.33 [95% CI 0.97-1.82]; p = 0.078) in TYK2 and rs1131454-AA in OAS1 (OR 1.29 [95% CI 0.95-1.75]; p = 0.110) were associated with higher severity. Therefore, these variants could influence the risk of severe COVID-19.
. 2024 Sep 5;14(1):20728.
doi: 10.1038/s41598-024-71476-2. Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
Pablo Delgado-Wicke[SUP] #[/SUP][SUP] 1 [/SUP], Sara Fernández de Córdoba-Oñate[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Emilia Roy-Vallejo[SUP] 5 [/SUP], Estíbaliz Alegría-Carrasco[SUP] 1 [/SUP], Diego A Rodríguez-Serrano[SUP] 6 [/SUP], Amalia Lamana[SUP] 7 [/SUP], Nuria Montes[SUP] 2 8 9 [/SUP], Ana Nicolao-Gómez[SUP] 1 [/SUP], Rosa Carracedo-Rodríguez[SUP] 1 [/SUP], Ana Marcos-Jiménez[SUP] 10 [/SUP], Paula Díaz-Fernández[SUP] 10 [/SUP], José M Galván-Román[SUP] 5 [/SUP], Laura Rabes-Rodríguez[SUP] 5 [/SUP], Marta Sanz-Alba[SUP] 5 [/SUP], Jesús Álvarez-Rodríguez[SUP] 5 [/SUP], Almudena Villa-Martí[SUP] 5 [/SUP], Carlos Rodríguez-Franco[SUP] 5 [/SUP], Gonzalo Villapalos-García[SUP] 11 12 [/SUP], Pablo Zubiaur[SUP] 11 12 [/SUP], Francisco Abad-Santos[SUP] 11 12 [/SUP], Ignacio de Los Santos[SUP] 5 13 [/SUP], Rosa P Gomariz[SUP] 7 [/SUP], Rosario García-Vicuña[SUP] 2 14 [/SUP], Cecilia Muñoz-Calleja[SUP] 10 14 13 [/SUP], Isidoro González-Álvaro[SUP] #[/SUP][SUP] 15 [/SUP], Elena Fernández-Ruiz[SUP] #[/SUP][SUP] 16 17 [/SUP]; PREDINMUN-COVID Group
Collaborators, Affiliations
- PMID: 39237611
- DOI: 10.1038/s41598-024-71476-2
The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (TYK2, STAT1, STAT4, OAS1, SOCS) and the vasoactive intestinal peptide and its receptors (VIP/VIPR1,2) were studied. To analyse the association between polymorphisms and severity, a model adjusted by age, sex and different comorbidities was generated by ordinal logistic regression. The genotypes rs8108236-AA (OR 0.12 [95% CI 0.02-0.53]; p = 0.007) and rs280519-AG (OR 0.74 [95% CI 0.56-0.99]; p = 0.03) in TYK2, and rs688136-CC (OR 0.7 [95% CI 0.5-0.99]; p = 0.046) in VIP, were associated with lower severity; in contrast, rs3853839-GG in TLR7 (OR 1.44 [95% CI 1.07-1.94]; p = 0.016), rs280500-AG (OR 1.33 [95% CI 0.97-1.82]; p = 0.078) in TYK2 and rs1131454-AA in OAS1 (OR 1.29 [95% CI 0.95-1.75]; p = 0.110) were associated with higher severity. Therefore, these variants could influence the risk of severe COVID-19.