tetano
Editor, Senior Moderator
Sci Rep
. 2021 Dec 30;11(1):24503.
doi: 10.1038/s41598-021-04279-4.
Humoral immune response to SARS-CoV-2 in five different groups of individuals at different environmental and professional risk of infection
Silvia Novello[SUP] #[/SUP][SUP] 1 [/SUP], Massimo Terzolo[SUP] #[/SUP][SUP] 2 [/SUP], Berchialla Paola[SUP] 2 [/SUP], Martina Gianetta[SUP] 1 [/SUP], Valentina Bianco[SUP] 1 [/SUP], Francesca Arizio[SUP] 1 [/SUP], Dalila Brero[SUP] 2 [/SUP], Anna Maria Elena Perini[SUP] 2 [/SUP], Adriana Boccuzzi[SUP] 3 [/SUP], Valeria Caramello[SUP] 3 [/SUP], Alberto Perboni[SUP] 4 [/SUP], Fabio Bellavia[SUP] 4 [/SUP], Giorgio Vittorio Scagliotti[SUP] #[/SUP][SUP] 5 [/SUP]
Affiliations
Abstract
It is partially unknown whether the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection persists with time. To address this issue, we detected the presence of SARS-CoV-2 antibodies in different groups of individuals previously diagnosed with COVID-19 disease (group 1 and 2), or potentially exposed to SARS-CoV-2 infection (group 3 and 4), and in a representative group of individuals with limited environmental exposure to the virus due to lockdown restrictions (group 5). The primary outcome was specific anti-SARS-CoV-2 antibodies in the different groups assessed by qualitative and quantitative analysis at baseline, 3 and 6 months follow-up. The seroconversion rate at baseline test was 95% in group 1, 61% in group 2, 40% in group 3, 17% in group 4 and 3% in group 5. Multivariate logistic regression analysis revealed male gender, close COVID-19 contact and presence of COVID-19 related symptoms strongly associated with serological positivity. The percentage of positive individuals as assessed by the qualitative and quantitative tests was superimposable. At the quantitative test, the median level of SARS-CoV-2 antibody levels measured in positive cases retested at 6-months increased significantly from baseline. The study indicates that assessing antibody response to SARS-CoV-2 through qualitative and quantitative testing is a reliable disease surveillance tool.
. 2021 Dec 30;11(1):24503.
doi: 10.1038/s41598-021-04279-4.
Humoral immune response to SARS-CoV-2 in five different groups of individuals at different environmental and professional risk of infection
Silvia Novello[SUP] #[/SUP][SUP] 1 [/SUP], Massimo Terzolo[SUP] #[/SUP][SUP] 2 [/SUP], Berchialla Paola[SUP] 2 [/SUP], Martina Gianetta[SUP] 1 [/SUP], Valentina Bianco[SUP] 1 [/SUP], Francesca Arizio[SUP] 1 [/SUP], Dalila Brero[SUP] 2 [/SUP], Anna Maria Elena Perini[SUP] 2 [/SUP], Adriana Boccuzzi[SUP] 3 [/SUP], Valeria Caramello[SUP] 3 [/SUP], Alberto Perboni[SUP] 4 [/SUP], Fabio Bellavia[SUP] 4 [/SUP], Giorgio Vittorio Scagliotti[SUP] #[/SUP][SUP] 5 [/SUP]
Affiliations
- PMID: 34969967
- DOI: 10.1038/s41598-021-04279-4
Abstract
It is partially unknown whether the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection persists with time. To address this issue, we detected the presence of SARS-CoV-2 antibodies in different groups of individuals previously diagnosed with COVID-19 disease (group 1 and 2), or potentially exposed to SARS-CoV-2 infection (group 3 and 4), and in a representative group of individuals with limited environmental exposure to the virus due to lockdown restrictions (group 5). The primary outcome was specific anti-SARS-CoV-2 antibodies in the different groups assessed by qualitative and quantitative analysis at baseline, 3 and 6 months follow-up. The seroconversion rate at baseline test was 95% in group 1, 61% in group 2, 40% in group 3, 17% in group 4 and 3% in group 5. Multivariate logistic regression analysis revealed male gender, close COVID-19 contact and presence of COVID-19 related symptoms strongly associated with serological positivity. The percentage of positive individuals as assessed by the qualitative and quantitative tests was superimposable. At the quantitative test, the median level of SARS-CoV-2 antibody levels measured in positive cases retested at 6-months increased significantly from baseline. The study indicates that assessing antibody response to SARS-CoV-2 through qualitative and quantitative testing is a reliable disease surveillance tool.