tetano
Editor, Senior Moderator
Sci Rep
. 2022 Mar 9;12(1):4150.
doi: 10.1038/s41598-022-08104-4.
Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c mice
Fumihiko Yasui[SUP] 1 [/SUP], Yusuke Matsumoto[SUP] 2 [/SUP], Naoki Yamamoto[SUP] 2 [/SUP], Takahiro Sanada[SUP] 2 [/SUP], Tomoko Honda[SUP] 2 [/SUP], Tsubasa Munakata[SUP] 2 [/SUP], Yasushi Itoh[SUP] 3 [/SUP], Michinori Kohara[SUP] 2 [/SUP]
Affiliations
Abstract
Models of animals that are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can usefully evaluate the efficacy of vaccines and therapeutics. In this study, we demonstrate that infection with the SARS-CoV-2 B.1.351 variant (TY8-612 strain) induces bodyweight loss and inflammatory cytokine/chemokine production in wild-type laboratory mice (BALB/c and C57BL/6 J mice). Furthermore, compared to their counterparts, BALB/c mice had a higher viral load in their lungs and worse symptoms. Importantly, infecting aged BALB/c mice (older than 6 months) with the TY8-612 strain elicited a massive and sustained production of multiple pro-inflammatory cytokines/chemokines and led to universal mortality. These results indicated that the SARS-CoV-2 B.1.351 variant-infected mice exhibited symptoms ranging from mild to fatal depending on their strain and age. Our data provide insights into the pathogenesis of SARS-CoV-2 and may be useful in developing prophylactics and therapeutics.
. 2022 Mar 9;12(1):4150.
doi: 10.1038/s41598-022-08104-4.
Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c mice
Fumihiko Yasui[SUP] 1 [/SUP], Yusuke Matsumoto[SUP] 2 [/SUP], Naoki Yamamoto[SUP] 2 [/SUP], Takahiro Sanada[SUP] 2 [/SUP], Tomoko Honda[SUP] 2 [/SUP], Tsubasa Munakata[SUP] 2 [/SUP], Yasushi Itoh[SUP] 3 [/SUP], Michinori Kohara[SUP] 2 [/SUP]
Affiliations
- PMID: 35264719
- DOI: 10.1038/s41598-022-08104-4
Abstract
Models of animals that are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can usefully evaluate the efficacy of vaccines and therapeutics. In this study, we demonstrate that infection with the SARS-CoV-2 B.1.351 variant (TY8-612 strain) induces bodyweight loss and inflammatory cytokine/chemokine production in wild-type laboratory mice (BALB/c and C57BL/6 J mice). Furthermore, compared to their counterparts, BALB/c mice had a higher viral load in their lungs and worse symptoms. Importantly, infecting aged BALB/c mice (older than 6 months) with the TY8-612 strain elicited a massive and sustained production of multiple pro-inflammatory cytokines/chemokines and led to universal mortality. These results indicated that the SARS-CoV-2 B.1.351 variant-infected mice exhibited symptoms ranging from mild to fatal depending on their strain and age. Our data provide insights into the pathogenesis of SARS-CoV-2 and may be useful in developing prophylactics and therapeutics.