tetano
Editor, Senior Moderator
Sci Rep
. 2021 Nov 22;11(1):22666.
doi: 10.1038/s41598-021-01215-4.
Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
Mattia Bellan[SUP] 1 2 3 [/SUP], Alessio Baricich[SUP] 4 5 [/SUP], Filippo Patrucco[SUP] 4 5 [/SUP], Patrizia Zeppegno[SUP] 4 5 [/SUP], Carla Gramaglia[SUP] 4 5 [/SUP], Piero Emilio Balbo[SUP] 5 [/SUP], Alessandro Carriero[SUP] 4 5 [/SUP], Chiara Santa Amico[SUP] 4 [/SUP], Gian Carlo Avanzi[SUP] 4 5 [/SUP], Michela Barini[SUP] 5 [/SUP], Marco Battaglia[SUP] 4 5 [/SUP], Simone Bor[SUP] 4 5 [/SUP], Vincenzo Cantaluppi[SUP] 4 5 [/SUP], Giuseppe Cappellano[SUP] 4 [/SUP], Federico Ceruti[SUP] 4 5 [/SUP], Annalisa Chiocchetti[SUP] 4 [/SUP], Elisa Clivati[SUP] 5 [/SUP], Mara Giordano[SUP] 4 5 [/SUP], Daria Cuneo[SUP] 4 5 [/SUP], Eleonora Gambaro[SUP] 4 5 [/SUP], Eleonora Gattoni[SUP] 5 [/SUP], Alberto Loro[SUP] 4 5 [/SUP], Marcello Manfredi[SUP] 4 [/SUP], Umberto Morosini[SUP] 4 [/SUP], Francesco Murano[SUP] 4 5 [/SUP], Elena Paracchini[SUP] 5 [/SUP], Giuseppe Patti[SUP] 4 5 [/SUP], David James Pinato[SUP] 4 6 [/SUP], Davide Raineri[SUP] 4 [/SUP], Roberta Rolla[SUP] 5 [/SUP], Pier Paolo Sainaghi[SUP] 4 5 [/SUP], Stefano Tricca[SUP] 4 [/SUP], Mario Pirisi[SUP] 4 5 [/SUP]
Affiliations
Abstract
Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363-369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
. 2021 Nov 22;11(1):22666.
doi: 10.1038/s41598-021-01215-4.
Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
Mattia Bellan[SUP] 1 2 3 [/SUP], Alessio Baricich[SUP] 4 5 [/SUP], Filippo Patrucco[SUP] 4 5 [/SUP], Patrizia Zeppegno[SUP] 4 5 [/SUP], Carla Gramaglia[SUP] 4 5 [/SUP], Piero Emilio Balbo[SUP] 5 [/SUP], Alessandro Carriero[SUP] 4 5 [/SUP], Chiara Santa Amico[SUP] 4 [/SUP], Gian Carlo Avanzi[SUP] 4 5 [/SUP], Michela Barini[SUP] 5 [/SUP], Marco Battaglia[SUP] 4 5 [/SUP], Simone Bor[SUP] 4 5 [/SUP], Vincenzo Cantaluppi[SUP] 4 5 [/SUP], Giuseppe Cappellano[SUP] 4 [/SUP], Federico Ceruti[SUP] 4 5 [/SUP], Annalisa Chiocchetti[SUP] 4 [/SUP], Elisa Clivati[SUP] 5 [/SUP], Mara Giordano[SUP] 4 5 [/SUP], Daria Cuneo[SUP] 4 5 [/SUP], Eleonora Gambaro[SUP] 4 5 [/SUP], Eleonora Gattoni[SUP] 5 [/SUP], Alberto Loro[SUP] 4 5 [/SUP], Marcello Manfredi[SUP] 4 [/SUP], Umberto Morosini[SUP] 4 [/SUP], Francesco Murano[SUP] 4 5 [/SUP], Elena Paracchini[SUP] 5 [/SUP], Giuseppe Patti[SUP] 4 5 [/SUP], David James Pinato[SUP] 4 6 [/SUP], Davide Raineri[SUP] 4 [/SUP], Roberta Rolla[SUP] 5 [/SUP], Pier Paolo Sainaghi[SUP] 4 5 [/SUP], Stefano Tricca[SUP] 4 [/SUP], Mario Pirisi[SUP] 4 5 [/SUP]
Affiliations
- PMID: 34811387
- DOI: 10.1038/s41598-021-01215-4
Abstract
Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363-369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.