tetano
Editor, Senior Moderator
Sci Rep
. 2021 Apr 1;11(1):7334.
doi: 10.1038/s41598-021-86676-3.
PaO [SUB]2[/SUB]/FiO [SUB]2[/SUB] and IL-6 are risk factors of mortality for intensive care COVID-19 patients
Yanli Gu[SUP] 1 [/SUP], Donghui Wang[SUP] 1 [/SUP], Cen Chen[SUP] 2 [/SUP], Wanjun Lu[SUP] 3 [/SUP], Hongbing Liu[SUP] 3 [/SUP], Tangfeng Lv[SUP] 3 [/SUP], Yong Song[SUP] 4 5 [/SUP], Fang Zhang[SUP] 6 7 [/SUP]
Affiliations
Abstract
To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB]) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928-0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826-0.943, p < 0.0001). Among the patients tested for IL-6, the PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] (OR = 0.955, 95%CI: 0.915-0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001-1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791-0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748-0.941, p < 0.0001) for PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB]. PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.
. 2021 Apr 1;11(1):7334.
doi: 10.1038/s41598-021-86676-3.
PaO [SUB]2[/SUB]/FiO [SUB]2[/SUB] and IL-6 are risk factors of mortality for intensive care COVID-19 patients
Yanli Gu[SUP] 1 [/SUP], Donghui Wang[SUP] 1 [/SUP], Cen Chen[SUP] 2 [/SUP], Wanjun Lu[SUP] 3 [/SUP], Hongbing Liu[SUP] 3 [/SUP], Tangfeng Lv[SUP] 3 [/SUP], Yong Song[SUP] 4 5 [/SUP], Fang Zhang[SUP] 6 7 [/SUP]
Affiliations
- PMID: 33795768
- DOI: 10.1038/s41598-021-86676-3
Abstract
To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB]) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928-0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826-0.943, p < 0.0001). Among the patients tested for IL-6, the PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] (OR = 0.955, 95%CI: 0.915-0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001-1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791-0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748-0.941, p < 0.0001) for PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB]. PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.