tetano
Editor, Senior Moderator
Sci Rep
. 2023 Sep 4;13(1):14529.
doi: 10.1038/s41598-023-41684-3. Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study
Hiromasa Yamamoto[SUP] #[/SUP][SUP] 1 [/SUP], Shinya Tanaka[SUP] #[/SUP][SUP] 1 [/SUP], Daisuke Kasugai[SUP] 2 [/SUP], Miho Shimizu[SUP] 3 [/SUP], Yohei Tsuchikawa[SUP] 1 [/SUP], Yuto Hori[SUP] 1 [/SUP], Yuki Fugane[SUP] 1 [/SUP], Takayuki Inoue[SUP] 1 [/SUP], Motoki Nagaya[SUP] 1 [/SUP], Norihito Omote[SUP] 4 [/SUP], Michiko Higashi[SUP] 5 [/SUP], Takanori Yamamoto[SUP] 5 [/SUP], Naruhiro Jingushi[SUP] 5 [/SUP], Atsushi Numaguchi[SUP] 5 [/SUP], Yukari Goto[SUP] 5 [/SUP], Yoshihiro Nishida[SUP] 1 6 [/SUP]
Affiliations
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.
. 2023 Sep 4;13(1):14529.
doi: 10.1038/s41598-023-41684-3. Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study
Hiromasa Yamamoto[SUP] #[/SUP][SUP] 1 [/SUP], Shinya Tanaka[SUP] #[/SUP][SUP] 1 [/SUP], Daisuke Kasugai[SUP] 2 [/SUP], Miho Shimizu[SUP] 3 [/SUP], Yohei Tsuchikawa[SUP] 1 [/SUP], Yuto Hori[SUP] 1 [/SUP], Yuki Fugane[SUP] 1 [/SUP], Takayuki Inoue[SUP] 1 [/SUP], Motoki Nagaya[SUP] 1 [/SUP], Norihito Omote[SUP] 4 [/SUP], Michiko Higashi[SUP] 5 [/SUP], Takanori Yamamoto[SUP] 5 [/SUP], Naruhiro Jingushi[SUP] 5 [/SUP], Atsushi Numaguchi[SUP] 5 [/SUP], Yukari Goto[SUP] 5 [/SUP], Yoshihiro Nishida[SUP] 1 6 [/SUP]
Affiliations
- PMID: 37666912
- DOI: 10.1038/s41598-023-41684-3
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.