tetano
Editor, Senior Moderator
Sci Rep
. 2024 Jul 16;14(1):16413.
doi: 10.1038/s41598-024-67536-2. Post-discharge spirometry evaluation in patients recovering from moderate-to-critical COVID-19: a cross-sectional study
Chee-Shee Chai[SUP] 1 [/SUP], Muhammad Amin Bin Ibrahim[SUP] 2 [/SUP], Nur Amira Binti Azhar[SUP] 3 [/SUP], Zulaika Binti Roslan[SUP] 3 [/SUP], Rozila Binti Harun[SUP] 3 [/SUP], Swarna Lata Krishnabahawan[SUP] 3 [/SUP], Aruna A P Karthigayan[SUP] 4 [/SUP], Roqiah Fatmawati Binti Abdul Kadir[SUP] 5 [/SUP], Busra Binti Johari[SUP] 5 [/SUP], Diana-Leh-Ching Ng[SUP] 6 [/SUP], Benedict-Lim-Heng Sim[SUP] 4 [/SUP], Chong-Kin Liam[SUP] 7 [/SUP], Abdul Razak Bin Muttalif[SUP] 8 [/SUP], Ahmad Hata Bin Rasit[SUP] 9 [/SUP], Kalaiarasu M Peariasamy[SUP] 10 [/SUP], Mohammed Fauzi Bin Abdul Rani[SUP] 11 [/SUP]
Affiliations
Understanding the prevalence of abnormal lung function and its associated factors among patients recovering from COVID-19 is crucial for enhancing post-COVID care strategies. This study primarily aimed to determine the prevalence and types of spirometry abnormalities among post-COVID-19 patients in Malaysia, with a secondary objective of identifying its associated factors. Conducted at the COVID-19 Research Clinic, Faculty of Medicine, University Technology MARA, from March 2021 to December 2022, this study included patients at least three months post-discharge from hospitals following moderate-to-critical COVID-19. Of 408 patients studied, abnormal spirometry was found in 46.8%, with 28.4% exhibiting a restrictive pattern, 17.4% showing preserved ratio impaired spirometry (PRISm), and 1.0% displaying an obstructive pattern. Factors independently associated with abnormal spirometry included consolidation on chest X-ray (OR 8.1, 95% CI 1.75-37.42, p = 0.008), underlying cardiovascular disease (OR 3.5, 95% CI 1.19-10.47, p = 0.023), ground-glass opacity on chest X-ray (OR 2.6, 95% CI 1.52-4.30, p < 0.001), and oxygen desaturation during the 6-min walk test (OR 1.9, 95% CI 1.20-3.06, p = 0.007). This study highlights that patients recovering from moderate-to-critical COVID-19 often exhibit abnormal spirometry, notably a restrictive pattern and PRISm. Routine spirometry screening for high-risk patients is recommended.
Keywords: COVID-19; Obstructive; PRISm; Radio-imaging; Restrictive; Spirometry.
. 2024 Jul 16;14(1):16413.
doi: 10.1038/s41598-024-67536-2. Post-discharge spirometry evaluation in patients recovering from moderate-to-critical COVID-19: a cross-sectional study
Chee-Shee Chai[SUP] 1 [/SUP], Muhammad Amin Bin Ibrahim[SUP] 2 [/SUP], Nur Amira Binti Azhar[SUP] 3 [/SUP], Zulaika Binti Roslan[SUP] 3 [/SUP], Rozila Binti Harun[SUP] 3 [/SUP], Swarna Lata Krishnabahawan[SUP] 3 [/SUP], Aruna A P Karthigayan[SUP] 4 [/SUP], Roqiah Fatmawati Binti Abdul Kadir[SUP] 5 [/SUP], Busra Binti Johari[SUP] 5 [/SUP], Diana-Leh-Ching Ng[SUP] 6 [/SUP], Benedict-Lim-Heng Sim[SUP] 4 [/SUP], Chong-Kin Liam[SUP] 7 [/SUP], Abdul Razak Bin Muttalif[SUP] 8 [/SUP], Ahmad Hata Bin Rasit[SUP] 9 [/SUP], Kalaiarasu M Peariasamy[SUP] 10 [/SUP], Mohammed Fauzi Bin Abdul Rani[SUP] 11 [/SUP]
Affiliations
- PMID: 39013943
- PMCID: PMC11252397
- DOI: 10.1038/s41598-024-67536-2
Understanding the prevalence of abnormal lung function and its associated factors among patients recovering from COVID-19 is crucial for enhancing post-COVID care strategies. This study primarily aimed to determine the prevalence and types of spirometry abnormalities among post-COVID-19 patients in Malaysia, with a secondary objective of identifying its associated factors. Conducted at the COVID-19 Research Clinic, Faculty of Medicine, University Technology MARA, from March 2021 to December 2022, this study included patients at least three months post-discharge from hospitals following moderate-to-critical COVID-19. Of 408 patients studied, abnormal spirometry was found in 46.8%, with 28.4% exhibiting a restrictive pattern, 17.4% showing preserved ratio impaired spirometry (PRISm), and 1.0% displaying an obstructive pattern. Factors independently associated with abnormal spirometry included consolidation on chest X-ray (OR 8.1, 95% CI 1.75-37.42, p = 0.008), underlying cardiovascular disease (OR 3.5, 95% CI 1.19-10.47, p = 0.023), ground-glass opacity on chest X-ray (OR 2.6, 95% CI 1.52-4.30, p < 0.001), and oxygen desaturation during the 6-min walk test (OR 1.9, 95% CI 1.20-3.06, p = 0.007). This study highlights that patients recovering from moderate-to-critical COVID-19 often exhibit abnormal spirometry, notably a restrictive pattern and PRISm. Routine spirometry screening for high-risk patients is recommended.
Keywords: COVID-19; Obstructive; PRISm; Radio-imaging; Restrictive; Spirometry.