tetano
Editor, Senior Moderator
Sci Rep
. 2023 Apr 26;13(1):6785.
doi: 10.1038/s41598-023-33783-y.
Prospective single-center study of health-related quality of life after COVID-19 in ICU and non-ICU patients
Johannes Herrmann[SUP] 1 [/SUP], Kerstin Müller[SUP] 1 [/SUP], Quirin Notz[SUP] 1 [/SUP], Martha Hübsch[SUP] 1 [/SUP], Kirsten Haas[SUP] 2 [/SUP], Anna Horn[SUP] 2 [/SUP], Julia Schmidt[SUP] 2 [/SUP], Peter Heuschmann[SUP] 2 3 [/SUP], Jens Maschmann[SUP] 4 [/SUP], Matthias Frosch[SUP] 5 [/SUP], Jürgen Deckert[SUP] 6 [/SUP], Hermann Einsele[SUP] 7 [/SUP], Georg Ertl[SUP] 8 [/SUP], Stefan Frantz[SUP] 9 [/SUP], Patrick Meybohm[SUP] 1 [/SUP], Christopher Lotz[SUP] 10 11 [/SUP]
Affiliations
Abstract
Long-term sequelae in hospitalized Coronavirus Disease 2019 (COVID-19) patients may result in limited quality of life. The current study aimed to determine health-related quality of life (HRQoL) after COVID-19 hospitalization in non-intensive care unit (ICU) and ICU patients. This is a single-center study at the University Hospital of Wuerzburg, Germany. Patients eligible were hospitalized with COVID-19 between March 2020 and December 2020. Patients were interviewed 3 and 12 months after hospital discharge. Questionnaires included the European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L), patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder 7 scale (GAD-7), FACIT fatigue scale, perceived stress scale (PSS-10) and posttraumatic symptom scale 10 (PTSS-10). 85 patients were included in the study. The EQ5D-5L-Index significantly differed between non-ICU (0.78 ± 0.33 and 0.84 ± 0.23) and ICU (0.71 ± 0.27; 0.74 ± 0.2) patients after 3- and 12-months. Of non-ICU 87% and 80% of ICU survivors lived at home without support after 12 months. One-third of ICU and half of the non-ICU patients returned to work. A higher percentage of ICU patients was limited in their activities of daily living compared to non-ICU patients. Depression and fatigue were present in one fifth of the ICU patients. Stress levels remained high with only 24% of non-ICU and 3% of ICU patients (p = 0.0186) having low perceived stress. Posttraumatic symptoms were present in 5% of non-ICU and 10% of ICU patients. HRQoL is limited in COVID-19 ICU patients 3- and 12-months post COVID-19 hospitalization, with significantly less improvement at 12-months compared to non-ICU patients. Mental disorders were common highlighting the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being post COVID-19.
. 2023 Apr 26;13(1):6785.
doi: 10.1038/s41598-023-33783-y.
Prospective single-center study of health-related quality of life after COVID-19 in ICU and non-ICU patients
Johannes Herrmann[SUP] 1 [/SUP], Kerstin Müller[SUP] 1 [/SUP], Quirin Notz[SUP] 1 [/SUP], Martha Hübsch[SUP] 1 [/SUP], Kirsten Haas[SUP] 2 [/SUP], Anna Horn[SUP] 2 [/SUP], Julia Schmidt[SUP] 2 [/SUP], Peter Heuschmann[SUP] 2 3 [/SUP], Jens Maschmann[SUP] 4 [/SUP], Matthias Frosch[SUP] 5 [/SUP], Jürgen Deckert[SUP] 6 [/SUP], Hermann Einsele[SUP] 7 [/SUP], Georg Ertl[SUP] 8 [/SUP], Stefan Frantz[SUP] 9 [/SUP], Patrick Meybohm[SUP] 1 [/SUP], Christopher Lotz[SUP] 10 11 [/SUP]
Affiliations
- PMID: 37100832
- DOI: 10.1038/s41598-023-33783-y
Abstract
Long-term sequelae in hospitalized Coronavirus Disease 2019 (COVID-19) patients may result in limited quality of life. The current study aimed to determine health-related quality of life (HRQoL) after COVID-19 hospitalization in non-intensive care unit (ICU) and ICU patients. This is a single-center study at the University Hospital of Wuerzburg, Germany. Patients eligible were hospitalized with COVID-19 between March 2020 and December 2020. Patients were interviewed 3 and 12 months after hospital discharge. Questionnaires included the European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L), patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder 7 scale (GAD-7), FACIT fatigue scale, perceived stress scale (PSS-10) and posttraumatic symptom scale 10 (PTSS-10). 85 patients were included in the study. The EQ5D-5L-Index significantly differed between non-ICU (0.78 ± 0.33 and 0.84 ± 0.23) and ICU (0.71 ± 0.27; 0.74 ± 0.2) patients after 3- and 12-months. Of non-ICU 87% and 80% of ICU survivors lived at home without support after 12 months. One-third of ICU and half of the non-ICU patients returned to work. A higher percentage of ICU patients was limited in their activities of daily living compared to non-ICU patients. Depression and fatigue were present in one fifth of the ICU patients. Stress levels remained high with only 24% of non-ICU and 3% of ICU patients (p = 0.0186) having low perceived stress. Posttraumatic symptoms were present in 5% of non-ICU and 10% of ICU patients. HRQoL is limited in COVID-19 ICU patients 3- and 12-months post COVID-19 hospitalization, with significantly less improvement at 12-months compared to non-ICU patients. Mental disorders were common highlighting the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being post COVID-19.