tetano
Editor, Senior Moderator
Sci Rep
. 2024 Mar 18;14(1):6454.
doi: 10.1038/s41598-024-56245-5. The microcirculation in the first days of ICU admission in critically ill COVID-19 patients is influenced by severity of disease
Fleur Brouwer[SUP] 1 [/SUP], Can Ince[SUP] 2 [/SUP], Jiska Pols[SUP] 1 [/SUP], Zühre Uz[SUP] 1 [/SUP], Matthias Peter Hilty[SUP] 3 [/SUP], Mendi Sesmu Arbous[SUP] 4 [/SUP]
Affiliations
The objective of this study was to investigate the relationship between sublingual microcirculatory parameters and the severity of the disease in critically ill coronavirus disease 2019 (COVID-19) patients in the initial period of Intensive Care Unit (ICU) admission in a phase of the COVID-19 pandemic where patients were being treated with anti-inflammatory medication. In total, 35 critically ill COVID-19 patients were included. Twenty-one critically ill COVID-19 patients with a Sequential Organ Failure Assessment (SOFA) score below or equal to 7 were compared to 14 critically ill COVID-19 patients with a SOFA score exceeding 7. All patients received dexamethasone and tocilizumab at ICU admission. Microcirculatory measurements were performed within the first five days of ICU admission, preferably as soon as possible after admission. An increase in diffusive capacity of the microcirculation (total vessel density, functional capillary density, capillary hematocrit) and increased perfusion of the tissues by red blood cells was found in the critically ill COVID-19 patients with a SOFA score of 7-9 compared to the critically ill COVID-19 patients with a SOFA score ≤ 7. No such effects were found in the convective component of the microcirculation. These effects occurred in the presence of administration of anti-inflammatory medication.
Keywords: Coronavirus disease 2019; Cytocam; Hypoxia; Inflammation; Sublingual microcirculation.
. 2024 Mar 18;14(1):6454.
doi: 10.1038/s41598-024-56245-5. The microcirculation in the first days of ICU admission in critically ill COVID-19 patients is influenced by severity of disease
Fleur Brouwer[SUP] 1 [/SUP], Can Ince[SUP] 2 [/SUP], Jiska Pols[SUP] 1 [/SUP], Zühre Uz[SUP] 1 [/SUP], Matthias Peter Hilty[SUP] 3 [/SUP], Mendi Sesmu Arbous[SUP] 4 [/SUP]
Affiliations
- PMID: 38499589
- PMCID: PMC10948764
- DOI: 10.1038/s41598-024-56245-5
The objective of this study was to investigate the relationship between sublingual microcirculatory parameters and the severity of the disease in critically ill coronavirus disease 2019 (COVID-19) patients in the initial period of Intensive Care Unit (ICU) admission in a phase of the COVID-19 pandemic where patients were being treated with anti-inflammatory medication. In total, 35 critically ill COVID-19 patients were included. Twenty-one critically ill COVID-19 patients with a Sequential Organ Failure Assessment (SOFA) score below or equal to 7 were compared to 14 critically ill COVID-19 patients with a SOFA score exceeding 7. All patients received dexamethasone and tocilizumab at ICU admission. Microcirculatory measurements were performed within the first five days of ICU admission, preferably as soon as possible after admission. An increase in diffusive capacity of the microcirculation (total vessel density, functional capillary density, capillary hematocrit) and increased perfusion of the tissues by red blood cells was found in the critically ill COVID-19 patients with a SOFA score of 7-9 compared to the critically ill COVID-19 patients with a SOFA score ≤ 7. No such effects were found in the convective component of the microcirculation. These effects occurred in the presence of administration of anti-inflammatory medication.
Keywords: Coronavirus disease 2019; Cytocam; Hypoxia; Inflammation; Sublingual microcirculation.