tetano
Editor, Senior Moderator
Sci Total Environ
. 2020 Aug 5;750:141532.
doi: 10.1016/j.scitotenv.2020.141532. Online ahead of print.
Particulate matter and SARS-CoV-2: A possible model of COVID-19 transmission
Nguyen Thanh Tung[SUP] 1 [/SUP], Po-Ching Cheng[SUP] 2 [/SUP], Kai-Hsien Chi[SUP] 3 [/SUP], Ta-Chi Hsiao[SUP] 4 [/SUP], Timothy Jones[SUP] 5 [/SUP], Kelly B?ruB?[SUP] 6 [/SUP], Kin-Fai Ho[SUP] 7 [/SUP], Hsiao-Chi Chuang[SUP] 8 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into a pandemic throughout the world. This disease is a highly infectious novel coronavirus and can affect people of all ages. Previous reports observed that particulate matter (PM) provided a platform for intermixing with viruses (i.e., influenza). However, the role of PM in SARS-CoV-2 transmission remains unclear. In this paper, we propose that PM plays a direct role as a "carrier" of SARS-CoV-2. SARS-CoV-2 is reported to have a high affinity for the angiotensin-converting enzyme 2 (ACE2) receptor. Indirectly, exposure to PM increases ACE2 expression in the lungs which facilitates SARS-CoV-2 viral adhesion. Thus, the high risk of SARS-CoV-2 in heavily polluted regions can be explained by upregulation of ACE2 caused by PM. PM could be both a direct and indirect transmission model for SARS-CoV-2 infection.
Keywords: Air pollution; Angiotensin-converting enzyme 2; Covid-19; SARS-CoV-2.
. 2020 Aug 5;750:141532.
doi: 10.1016/j.scitotenv.2020.141532. Online ahead of print.
Particulate matter and SARS-CoV-2: A possible model of COVID-19 transmission
Nguyen Thanh Tung[SUP] 1 [/SUP], Po-Ching Cheng[SUP] 2 [/SUP], Kai-Hsien Chi[SUP] 3 [/SUP], Ta-Chi Hsiao[SUP] 4 [/SUP], Timothy Jones[SUP] 5 [/SUP], Kelly B?ruB?[SUP] 6 [/SUP], Kin-Fai Ho[SUP] 7 [/SUP], Hsiao-Chi Chuang[SUP] 8 [/SUP]
Affiliations
- PMID: 32858292
- DOI: 10.1016/j.scitotenv.2020.141532
Abstract
Coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into a pandemic throughout the world. This disease is a highly infectious novel coronavirus and can affect people of all ages. Previous reports observed that particulate matter (PM) provided a platform for intermixing with viruses (i.e., influenza). However, the role of PM in SARS-CoV-2 transmission remains unclear. In this paper, we propose that PM plays a direct role as a "carrier" of SARS-CoV-2. SARS-CoV-2 is reported to have a high affinity for the angiotensin-converting enzyme 2 (ACE2) receptor. Indirectly, exposure to PM increases ACE2 expression in the lungs which facilitates SARS-CoV-2 viral adhesion. Thus, the high risk of SARS-CoV-2 in heavily polluted regions can be explained by upregulation of ACE2 caused by PM. PM could be both a direct and indirect transmission model for SARS-CoV-2 infection.
Keywords: Air pollution; Angiotensin-converting enzyme 2; Covid-19; SARS-CoV-2.