tetano
Editor, Senior Moderator
Science
. 2023 Oct 6;382(6666):eadj0070.
doi: 10.1126/science.adj0070. Epub 2023 Oct 6. Mapping SARS-CoV-2 antigenic relationships and serological responses
Samuel H Wilks[SUP] #[/SUP][SUP] 1 [/SUP], Barbara Mühlemann[SUP] #[/SUP][SUP] 2 3 [/SUP], Xiaoying Shen[SUP] #[/SUP][SUP] 4 5 [/SUP], Sina Türeli[SUP] 1 [/SUP], Eric B LeGresley[SUP] 1 [/SUP], Antonia Netzl[SUP] 1 [/SUP], Miguela A Caniza[SUP] 6 [/SUP], Jesus N Chacaltana-Huarcaya[SUP] 7 [/SUP], Victor M Corman[SUP] 2 3 [/SUP], Xiaoju Daniell[SUP] 4 [/SUP], Michael B Datto[SUP] 8 [/SUP], Fatimah S Dawood[SUP] 9 [/SUP], Thomas N Denny[SUP] 5 [/SUP], Christian Drosten[SUP] 2 3 [/SUP], Ron A M Fouchier[SUP] 10 [/SUP], Patricia J Garcia[SUP] 11 [/SUP], Peter J Halfmann[SUP] 12 [/SUP], Agatha Jassem[SUP] 13 [/SUP], Lara M Jeworowski[SUP] 2 [/SUP], Terry C Jones[SUP] 1 2 3 [/SUP], Yoshihiro Kawaoka[SUP] 12 14 15 16 [/SUP], Florian Krammer[SUP] 17 18 [/SUP], Charlene McDanal[SUP] 4 [/SUP], Rolando Pajon[SUP] 19 [/SUP], Viviana Simon[SUP] 17 18 20 21 [/SUP], Melissa S Stockwell[SUP] 22 [/SUP], Haili Tang[SUP] 4 [/SUP], Harm van Bakel[SUP] 23 [/SUP], Vic Veguilla[SUP] 9 [/SUP], Richard Webby[SUP] 24 [/SUP], David C Montefiori[SUP] 4 5 [/SUP], Derek J Smith[SUP] 1 [/SUP]
Affiliations
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)-1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.
. 2023 Oct 6;382(6666):eadj0070.
doi: 10.1126/science.adj0070. Epub 2023 Oct 6. Mapping SARS-CoV-2 antigenic relationships and serological responses
Samuel H Wilks[SUP] #[/SUP][SUP] 1 [/SUP], Barbara Mühlemann[SUP] #[/SUP][SUP] 2 3 [/SUP], Xiaoying Shen[SUP] #[/SUP][SUP] 4 5 [/SUP], Sina Türeli[SUP] 1 [/SUP], Eric B LeGresley[SUP] 1 [/SUP], Antonia Netzl[SUP] 1 [/SUP], Miguela A Caniza[SUP] 6 [/SUP], Jesus N Chacaltana-Huarcaya[SUP] 7 [/SUP], Victor M Corman[SUP] 2 3 [/SUP], Xiaoju Daniell[SUP] 4 [/SUP], Michael B Datto[SUP] 8 [/SUP], Fatimah S Dawood[SUP] 9 [/SUP], Thomas N Denny[SUP] 5 [/SUP], Christian Drosten[SUP] 2 3 [/SUP], Ron A M Fouchier[SUP] 10 [/SUP], Patricia J Garcia[SUP] 11 [/SUP], Peter J Halfmann[SUP] 12 [/SUP], Agatha Jassem[SUP] 13 [/SUP], Lara M Jeworowski[SUP] 2 [/SUP], Terry C Jones[SUP] 1 2 3 [/SUP], Yoshihiro Kawaoka[SUP] 12 14 15 16 [/SUP], Florian Krammer[SUP] 17 18 [/SUP], Charlene McDanal[SUP] 4 [/SUP], Rolando Pajon[SUP] 19 [/SUP], Viviana Simon[SUP] 17 18 20 21 [/SUP], Melissa S Stockwell[SUP] 22 [/SUP], Haili Tang[SUP] 4 [/SUP], Harm van Bakel[SUP] 23 [/SUP], Vic Veguilla[SUP] 9 [/SUP], Richard Webby[SUP] 24 [/SUP], David C Montefiori[SUP] 4 5 [/SUP], Derek J Smith[SUP] 1 [/SUP]
Affiliations
- PMID: 37797027
- DOI: 10.1126/science.adj0070
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)-1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.