tetano
Editor, Senior Moderator
Science. 2015 Sep 4;349(6252):aaa4352. doi: 10.1126/science.aaa4352.
[h=1]Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.[/h] Lim K[SUP]1[/SUP], Hyun YM[SUP]1[/SUP], Lambert-Emo K[SUP]1[/SUP], Capece T[SUP]1[/SUP], Bae S[SUP]1[/SUP], Miller R[SUP]2[/SUP], Topham DJ[SUP]1[/SUP], Kim M[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.
Copyright ? 2015, American Association for the Advancement of Science.
[h=3]Comment in[/h]
PMID: 26339033 [PubMed - in process]
[h=1]Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.[/h] Lim K[SUP]1[/SUP], Hyun YM[SUP]1[/SUP], Lambert-Emo K[SUP]1[/SUP], Capece T[SUP]1[/SUP], Bae S[SUP]1[/SUP], Miller R[SUP]2[/SUP], Topham DJ[SUP]1[/SUP], Kim M[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.
Copyright ? 2015, American Association for the Advancement of Science.
[h=3]Comment in[/h]
- IMMUNOLOGY. Fragmented communication between immune cells. [Science. 2015]
PMID: 26339033 [PubMed - in process]