tetano
Editor, Senior Moderator
Clin Infect Dis. 2018 Sep 20. doi: 10.1093/cid/ciy812. [Epub ahead of print]
[h=1]Seasonal Influenza Vaccine Impact on Pandemic H1N1 Vaccine Efficacy.[/h] Lee RU[SUP]1[/SUP], Phillips CJ[SUP]2[/SUP], Faix DJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] In 2009, a novel influenza A (pH1N1) was identified, resulting in a pandemic with significant morbidity and mortality. A monovalent pH1N1 vaccine was separately produced in addition to the seasonal trivalent influenza vaccine. Formulation of the seasonal influenza vaccine (injectable trivalent inactivated influenza vaccine [TIV] vs. intranasal live, attenuated influenza vaccine [LAIV]) was postulated to have impacted the efficacy of the pH1N1 vaccination.
[h=4]Methods:[/h] We reviewed electronic health and manpower databases, which included vaccination records, along with healthcare encounters for influenza-like illness (ILI), influenza, and pneumonia among US military members (aged 18-49 years) in the contiguous United States. We examined rates by vaccination type to identify potential factors associated with the risk for study outcomes.
[h=4]Results:[/h] Compared with those receiving the seasonal influenza vaccine alone, subjects receiving the pH1N1 vaccine, either alone (RR, 0.49) or in addition to the seasonal vaccine (RR, 0.51), had an approximately 50% reduction in ILI, 88% reduction in influenza (RR, 0.11 and 0.12, respectively), and 63% reduction in pneumonia (RR, 0.37 and 0.35, respectively). There was no clinically significant difference in ILI, influenza, or pneumonia attack rates among those receiving the pH1N1 vaccine with or without presence of the seasonal vaccine. Similarly, there was no clinically relevant difference in pH1N1 effectiveness between seasonal TIV and LAIV recipients.
[h=4]Conclusions:[/h] During the 2009-2010 pandemic, the pH1N1 vaccination was effective in reducing rates of ILI, influenza, and pneumonia in young healthy adults. Administration of the seasonal vaccine should continue without concern of potential interference with a novel pandemic vaccine, though more studies are needed to determine if this is applicable to other influenza seasons.
PMID: 30239636 DOI: 10.1093/cid/ciy812
[h=1]Seasonal Influenza Vaccine Impact on Pandemic H1N1 Vaccine Efficacy.[/h] Lee RU[SUP]1[/SUP], Phillips CJ[SUP]2[/SUP], Faix DJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] In 2009, a novel influenza A (pH1N1) was identified, resulting in a pandemic with significant morbidity and mortality. A monovalent pH1N1 vaccine was separately produced in addition to the seasonal trivalent influenza vaccine. Formulation of the seasonal influenza vaccine (injectable trivalent inactivated influenza vaccine [TIV] vs. intranasal live, attenuated influenza vaccine [LAIV]) was postulated to have impacted the efficacy of the pH1N1 vaccination.
[h=4]Methods:[/h] We reviewed electronic health and manpower databases, which included vaccination records, along with healthcare encounters for influenza-like illness (ILI), influenza, and pneumonia among US military members (aged 18-49 years) in the contiguous United States. We examined rates by vaccination type to identify potential factors associated with the risk for study outcomes.
[h=4]Results:[/h] Compared with those receiving the seasonal influenza vaccine alone, subjects receiving the pH1N1 vaccine, either alone (RR, 0.49) or in addition to the seasonal vaccine (RR, 0.51), had an approximately 50% reduction in ILI, 88% reduction in influenza (RR, 0.11 and 0.12, respectively), and 63% reduction in pneumonia (RR, 0.37 and 0.35, respectively). There was no clinically significant difference in ILI, influenza, or pneumonia attack rates among those receiving the pH1N1 vaccine with or without presence of the seasonal vaccine. Similarly, there was no clinically relevant difference in pH1N1 effectiveness between seasonal TIV and LAIV recipients.
[h=4]Conclusions:[/h] During the 2009-2010 pandemic, the pH1N1 vaccination was effective in reducing rates of ILI, influenza, and pneumonia in young healthy adults. Administration of the seasonal vaccine should continue without concern of potential interference with a novel pandemic vaccine, though more studies are needed to determine if this is applicable to other influenza seasons.
PMID: 30239636 DOI: 10.1093/cid/ciy812