tetano
Editor, Senior Moderator
J Infect Dis. 2018 Apr 13. doi: 10.1093/infdis/jiy210. [Epub ahead of print]
[h=1]Secondary Bacterial Pneumonia by Staphylococcus aureus following Influenza A Infection Is SaeR/S Dependent.[/h] Borgogna TR[SUP]1[/SUP], Hisey B[SUP]1[/SUP], Heitmann E[SUP]1[/SUP], Obar JJ[SUP]2[/SUP], Meissner N[SUP]1[/SUP], Voyich JM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] S. aureus is a predominant cause of fatal pneumonia following influenza A virus (IAV) infection. Herein we investigate the influence of antecedent IAV infection on S. aureus virulence gene expression. Using a murine model, comparing USA300 and USA300ΔsaeR/S strains, we demonstrate S. aureus pathogenesis following IAV infection is SaeR/S dependent. Furthermore, we show that IAV modulates the lung environment to rapidly up-regulate S. aureus virulence factors containing the SaeR-binding domain. Data demonstrate the pathogen response to IAV infection impacts host outcome and provides evidence that the ability of S. aureus to sense-and-respond to the lung environment determines severity of pneumonia.
PMID: 29668950 DOI: 10.1093/infdis/jiy210
[h=1]Secondary Bacterial Pneumonia by Staphylococcus aureus following Influenza A Infection Is SaeR/S Dependent.[/h] Borgogna TR[SUP]1[/SUP], Hisey B[SUP]1[/SUP], Heitmann E[SUP]1[/SUP], Obar JJ[SUP]2[/SUP], Meissner N[SUP]1[/SUP], Voyich JM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] S. aureus is a predominant cause of fatal pneumonia following influenza A virus (IAV) infection. Herein we investigate the influence of antecedent IAV infection on S. aureus virulence gene expression. Using a murine model, comparing USA300 and USA300ΔsaeR/S strains, we demonstrate S. aureus pathogenesis following IAV infection is SaeR/S dependent. Furthermore, we show that IAV modulates the lung environment to rapidly up-regulate S. aureus virulence factors containing the SaeR-binding domain. Data demonstrate the pathogen response to IAV infection impacts host outcome and provides evidence that the ability of S. aureus to sense-and-respond to the lung environment determines severity of pneumonia.
PMID: 29668950 DOI: 10.1093/infdis/jiy210