tetano
Editor, Senior Moderator
Int J Infect Dis. 2011 Aug 18. [Epub ahead of print]
Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method.
Elizondo-Montemayor L, Alvarez MM, Hern?ndez-Torre M, Ugalde-Casas PA, Lam-Franco L, Bustamante-Careaga H, Castilleja-Leal F, Contreras-Castillo J, Moreno-S?nchez H, Tamargo-Barrera D, L?pez-Pacheco F, Freiden PJ, Schultz-Cherry S.
Source
School of Medicine, Instituto Tecnol?gico y de Estudios Superiores de Monterrey, Av. Morones Prieto 3000 Pte. Col. Los Doctores, CP 64710, Monterrey, Nuevo Le?n, Mexico.
Abstract
OBJECTIVE:
No serological studies have been performed in Mexico to assess the seroprevalence of influenza A/H1N1/2009 in groups of people according to the potential risk of transmission. The aim of this study was to determine the seroprevalence of antibodies against influenza A/H1N1/2009 in subjects in Mexico grouped by risk of transmission.
METHODS:
Two thousand two hundred and twenty-two subjects were categorized into one of five occupation groups according to the potential risk of transmission: (1) students, (2) teachers, (3) healthcare workers, (4) institutional home residents aged >60 years, and (5) general population. Seroprevalence by potential transmission group and by age grouped into decades was determined by a virus-free ELISA method based on the recombinant receptor-binding domain of the hemagglutinin of influenza A/H1N1/2009 virus as antigen (85% sensitivity; 95% specificity). The Wilson score, Chi-square test, and logistic regression models were used for the statistical analyses.
RESULTS:
Seroprevalence for students was 47.3%, for teachers was 33.9%, for older adults was 36.5%, and for the general population was 33.0%, however it was only 24.6% for healthcare workers (p=0.011). Of the students, 56.6% of those at middle school, 56.4% of those at high school, 52.7% of those at elementary school, and 31.1% of college students showed positive antibodies (p<0.001). Seroprevalence was 44.6% for college teachers, 31.6% for middle school teachers, and 29.8% for elementary school teachers, but was only 20.3% for high school teachers (p=0.002).
CONCLUSIONS:
The student group was the group most affected by influenza A/H1N1/2009, while the healthcare worker group showed the lowest prevalence. Students represent a key target for preventive measures.
Copyright ? 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PMID:
21855383
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21855383
Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method.
Elizondo-Montemayor L, Alvarez MM, Hern?ndez-Torre M, Ugalde-Casas PA, Lam-Franco L, Bustamante-Careaga H, Castilleja-Leal F, Contreras-Castillo J, Moreno-S?nchez H, Tamargo-Barrera D, L?pez-Pacheco F, Freiden PJ, Schultz-Cherry S.
Source
School of Medicine, Instituto Tecnol?gico y de Estudios Superiores de Monterrey, Av. Morones Prieto 3000 Pte. Col. Los Doctores, CP 64710, Monterrey, Nuevo Le?n, Mexico.
Abstract
OBJECTIVE:
No serological studies have been performed in Mexico to assess the seroprevalence of influenza A/H1N1/2009 in groups of people according to the potential risk of transmission. The aim of this study was to determine the seroprevalence of antibodies against influenza A/H1N1/2009 in subjects in Mexico grouped by risk of transmission.
METHODS:
Two thousand two hundred and twenty-two subjects were categorized into one of five occupation groups according to the potential risk of transmission: (1) students, (2) teachers, (3) healthcare workers, (4) institutional home residents aged >60 years, and (5) general population. Seroprevalence by potential transmission group and by age grouped into decades was determined by a virus-free ELISA method based on the recombinant receptor-binding domain of the hemagglutinin of influenza A/H1N1/2009 virus as antigen (85% sensitivity; 95% specificity). The Wilson score, Chi-square test, and logistic regression models were used for the statistical analyses.
RESULTS:
Seroprevalence for students was 47.3%, for teachers was 33.9%, for older adults was 36.5%, and for the general population was 33.0%, however it was only 24.6% for healthcare workers (p=0.011). Of the students, 56.6% of those at middle school, 56.4% of those at high school, 52.7% of those at elementary school, and 31.1% of college students showed positive antibodies (p<0.001). Seroprevalence was 44.6% for college teachers, 31.6% for middle school teachers, and 29.8% for elementary school teachers, but was only 20.3% for high school teachers (p=0.002).
CONCLUSIONS:
The student group was the group most affected by influenza A/H1N1/2009, while the healthcare worker group showed the lowest prevalence. Students represent a key target for preventive measures.
Copyright ? 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PMID:
21855383
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21855383