tetano
Editor, Senior Moderator
Fitoterapia. 2013 Nov 14. pii: S0367-326X(13)00297-9. doi: 10.1016/j.fitote.2013.11.002. [Epub ahead of print]
Seven new Cassane furanoditerpenes from the Seeds of Caesalpinia minax.
Wu J, Chen G, Xu X, Huo X, Wu S, Wu Z, Gao H.
Source
Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Abstract
A bioassay-guided study led to the isolation of seven new cassane furanoditerpenes, designated as spirocaesalmin B (1), caesalpinin M1 (2), caesalpinin M2 (3), caesalmin E1 (4), caesalmin E2 (5), caesalmin E3 (6), caesalpinin F1 (7) and three known compounds neocaesalpin A(8), neocaesalpin L(9, neocaesalpin L1(10) from the seeds of Caesalpinia minax Hance. Compounds structures were determined on the basis of extensive spectroscopic analyses, including X-ray crystallographic analysis, HRESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, NOESY) methods. Some absolute configurations were confirmed via the circular dichroism (CD) spectra. Compound 1 is the first example of an A-seco-rearranged cassane furanoditerpene with an unusual skeleton isolated from the genus Caesalpinia. All compounds inhibitory effects on influenza virus neuraminidase (NA) in vitro were valued for the first time. Compared with the positive control (Zanamivir), new compounds were found to show moderate inhibitory activity.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
Caesalpinia minax Hance, anti-neuraminidase activity, cassane, furanoditerpenes
PMID:
24239746
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24239746
Seven new Cassane furanoditerpenes from the Seeds of Caesalpinia minax.
Wu J, Chen G, Xu X, Huo X, Wu S, Wu Z, Gao H.
Source
Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Abstract
A bioassay-guided study led to the isolation of seven new cassane furanoditerpenes, designated as spirocaesalmin B (1), caesalpinin M1 (2), caesalpinin M2 (3), caesalmin E1 (4), caesalmin E2 (5), caesalmin E3 (6), caesalpinin F1 (7) and three known compounds neocaesalpin A(8), neocaesalpin L(9, neocaesalpin L1(10) from the seeds of Caesalpinia minax Hance. Compounds structures were determined on the basis of extensive spectroscopic analyses, including X-ray crystallographic analysis, HRESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, NOESY) methods. Some absolute configurations were confirmed via the circular dichroism (CD) spectra. Compound 1 is the first example of an A-seco-rearranged cassane furanoditerpene with an unusual skeleton isolated from the genus Caesalpinia. All compounds inhibitory effects on influenza virus neuraminidase (NA) in vitro were valued for the first time. Compared with the positive control (Zanamivir), new compounds were found to show moderate inhibitory activity.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
Caesalpinia minax Hance, anti-neuraminidase activity, cassane, furanoditerpenes
PMID:
24239746
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24239746