Mary Wilson
Well-known member
Published: 12 January 2024
The Journal of Infectious Diseases, jiad567, https://doi.org/10.1093/infdis/jiad567
Leila Fotooh Abadi,1,2 Madhav B. Sharma,1 and Theodoros Kelesidis1,2
Abstract
The complexity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its variants in lung cells can truly be characterized only at the tissue and protein levels among unique cell subtypes. However, in vivo data are limited due to lack of accessible human tissues. Using a transgenic mouse model of SARS-CoV-2 infection and flow cytometry, we provide in vivo novel insight at the protein level that the differential impact of SARS-CoV-2 (Wuhan strain) and its B.1.617.2 (Delta) and BA.1 (Omicron) variants on lung may be attributed to differential patterns of viral protein levels among ciliated airway cells, alveolar types 1 and 2 cells, immune cells, and endothelial lung cells.
https://watermark.silverchair.com/j...bVl_RfKe3YPGAhxnPAbwAp2m9NFsfTnYlOTuDGckk1G6A
The Journal of Infectious Diseases, jiad567, https://doi.org/10.1093/infdis/jiad567
Leila Fotooh Abadi,1,2 Madhav B. Sharma,1 and Theodoros Kelesidis1,2
Abstract
The complexity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its variants in lung cells can truly be characterized only at the tissue and protein levels among unique cell subtypes. However, in vivo data are limited due to lack of accessible human tissues. Using a transgenic mouse model of SARS-CoV-2 infection and flow cytometry, we provide in vivo novel insight at the protein level that the differential impact of SARS-CoV-2 (Wuhan strain) and its B.1.617.2 (Delta) and BA.1 (Omicron) variants on lung may be attributed to differential patterns of viral protein levels among ciliated airway cells, alveolar types 1 and 2 cells, immune cells, and endothelial lung cells.
https://watermark.silverchair.com/j...bVl_RfKe3YPGAhxnPAbwAp2m9NFsfTnYlOTuDGckk1G6A