tetano
Editor, Senior Moderator
J Virol. 2013 Aug 14. [Epub ahead of print]
Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses.
Wang Q, Chen X, Feng J, Cao Y, Song Y, Wang H, Zhu C, Liu S, Zhu Y.
Source
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Abstract
The interleukin-6 receptor, which exists as membrane-bound and soluble forms, plays critical roles in the immune response. The soluble receptor (sIL6R) has been identified as a potential therapeutic target for preventing coronary heart disease. However, little is known about the role of this receptor during viral infection. In this study, we show that sIL6R but not IL6 is induced by viral infection via the cyclooxygenase-2 pathway. Interestingly, sIL6R but not IL6 exhibited extensive antiviral activity to DNA and RNA viruses including hepatitis B virus, influenza virus, enterovirus-71, and vesicular stomatitis virus. Synergistic effects on antiviral action were not observed by combination of sIL6R and IL6. Furthermore, sIL6R mediated antiviral action via p28 pathway, and induced IFNα by promoting IRF3 and NF-κB nuclear translocation, which led to activation of IFN downstream effectors including OAS, PKR, and Mx. Thus, our results demonstrate that sIL6R, but not IL6, plays an important role in the host antiviral response.
PMID:
23946454
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23946454
Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses.
Wang Q, Chen X, Feng J, Cao Y, Song Y, Wang H, Zhu C, Liu S, Zhu Y.
Source
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Abstract
The interleukin-6 receptor, which exists as membrane-bound and soluble forms, plays critical roles in the immune response. The soluble receptor (sIL6R) has been identified as a potential therapeutic target for preventing coronary heart disease. However, little is known about the role of this receptor during viral infection. In this study, we show that sIL6R but not IL6 is induced by viral infection via the cyclooxygenase-2 pathway. Interestingly, sIL6R but not IL6 exhibited extensive antiviral activity to DNA and RNA viruses including hepatitis B virus, influenza virus, enterovirus-71, and vesicular stomatitis virus. Synergistic effects on antiviral action were not observed by combination of sIL6R and IL6. Furthermore, sIL6R mediated antiviral action via p28 pathway, and induced IFNα by promoting IRF3 and NF-κB nuclear translocation, which led to activation of IFN downstream effectors including OAS, PKR, and Mx. Thus, our results demonstrate that sIL6R, but not IL6, plays an important role in the host antiviral response.
PMID:
23946454
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23946454