tetano
Editor, Senior Moderator
J Nat Prod. 2014 Feb 4. [Epub ahead of print]
Sorbicatechols A and B, Antiviral Sorbicillinoids from the Marine-Derived Fungus Penicillium chrysogenum PJX-17.
Peng J, Zhang X, Du L, Wang W, Zhu T, Gu Q, Li D.
Author information
Abstract
Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.
PMID:
24495078
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24495078
Sorbicatechols A and B, Antiviral Sorbicillinoids from the Marine-Derived Fungus Penicillium chrysogenum PJX-17.
Peng J, Zhang X, Du L, Wang W, Zhu T, Gu Q, Li D.
Author information
Abstract
Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.
PMID:
24495078
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24495078