tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Nov 5. doi: 10.1111/irv.12011. [Epub ahead of print]
Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada.
Schanzer DL, McGeer A, Morris K.
Source
Infectious Disease Prevention and Control Branch, Public Health Agency of Canada, Ottawa, ON, Canada. Department of Microbiology, Mount Sinai Hospital, Toronto, ON, Canada. Department of Microbiology, University of Toronto, Toronto, ON, Canada. Health System Analysis & Emerging Issues, Canadian Institute for Health Information (CIHI), Toronto, ON, Canada.
Abstract
Please cite this paper as: Schanzer et al. (2012) Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12011. Background The number of admissions to hospital for which influenza is laboratory confirmed is considered to be a substantial underestimate of the true number of admissions due to an influenza infection. During the 2009 pandemic, testing for influenza in hospitalized patients was a priority, but the ascertainment rate remains uncertain. Methods The discharge abstracts of persons admitted with any respiratory condition were extracted from the Canadian Discharge Abstract Database, for April 2003-March 2010. Stratified, weekly admissions were modeled as a function of viral activity, seasonality, and trend using Poisson regression models. Results An estimated 1 out of every 6?4 admissions attributable to seasonal influenza (2003-April 2009) were coded to J10 (influenza virus identified). During the 2009 pandemic (May-March 2010), the influenza virus was identified in 1 of 1?6 admissions (95% CI, 1?5-1?7) attributed to the pandemic strain. Compared with previous H1N1 seasons (2007/08, 2008/09), the influenza-attributed hospitalization rate for persons <65 years was approximately six times higher during the 2009 H1N1 pandemic, whereas for persons 75 years or older, the pandemic rate was approximately fivefold lower. Conclusions Case ascertainment was much improved during the pandemic period, with under ascertainment of admissions due to H1N1/2009 limited primarily to patients with a diagnosis of pneumonia.
? 2012 Blackwell Publishing Ltd and Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister of the Public Health Agency of Canada.
PMID:
23122189
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23122189
Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada.
Schanzer DL, McGeer A, Morris K.
Source
Infectious Disease Prevention and Control Branch, Public Health Agency of Canada, Ottawa, ON, Canada. Department of Microbiology, Mount Sinai Hospital, Toronto, ON, Canada. Department of Microbiology, University of Toronto, Toronto, ON, Canada. Health System Analysis & Emerging Issues, Canadian Institute for Health Information (CIHI), Toronto, ON, Canada.
Abstract
Please cite this paper as: Schanzer et al. (2012) Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12011. Background The number of admissions to hospital for which influenza is laboratory confirmed is considered to be a substantial underestimate of the true number of admissions due to an influenza infection. During the 2009 pandemic, testing for influenza in hospitalized patients was a priority, but the ascertainment rate remains uncertain. Methods The discharge abstracts of persons admitted with any respiratory condition were extracted from the Canadian Discharge Abstract Database, for April 2003-March 2010. Stratified, weekly admissions were modeled as a function of viral activity, seasonality, and trend using Poisson regression models. Results An estimated 1 out of every 6?4 admissions attributable to seasonal influenza (2003-April 2009) were coded to J10 (influenza virus identified). During the 2009 pandemic (May-March 2010), the influenza virus was identified in 1 of 1?6 admissions (95% CI, 1?5-1?7) attributed to the pandemic strain. Compared with previous H1N1 seasons (2007/08, 2008/09), the influenza-attributed hospitalization rate for persons <65 years was approximately six times higher during the 2009 H1N1 pandemic, whereas for persons 75 years or older, the pandemic rate was approximately fivefold lower. Conclusions Case ascertainment was much improved during the pandemic period, with under ascertainment of admissions due to H1N1/2009 limited primarily to patients with a diagnosis of pneumonia.
? 2012 Blackwell Publishing Ltd and Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister of the Public Health Agency of Canada.
PMID:
23122189
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23122189