Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth

[tetano]

Molecules. 2014 Apr 10;19(4):4479-90. doi: 10.3390/molecules19044479.
Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth.
Kang J1, Liu C2, Wang H3, Li B4, Li C2, Chen R5, Liu A6.
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Abstract

One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (-)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (-)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1-4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.

PMID:
24727419
[PubMed - in process]

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http://www.ncbi.nlm.nih.gov/pubmed/24727419