sharon sanders
Editor-in-Chief & President
Eurosurveillance, Volume 19, Issue 25, 26 June 2014
Surveillance and outbreak reports
TWO CLUSTERED CASES OF CONFIRMED INFLUENZA A(H5N1) VIRUS INFECTION, CAMBODIA, 2011
N Chea1, S D Yi2, S Rith3, H Seng2, V Ieng1, C Penh2, S Mardy1, D Laurent4, B Richner4, T Sok2, S Ly2, P Kitsutani5, N Asgari1, M C Roces1, P Buchy3,6, A Tarantola ()3,6
World Health Organization, Phnom Penh, Cambodia
Communicable Disease Control Department, Ministry of Health, Phnom Penh, Cambodia
Institut Pasteur du Cambodge, Phnom Penh, Cambodia
Jayavaraman VII Children Hospital, Kantha Bopha Foundation, Siem Reap City, Cambodia
United States? Centers for Disease Control and Prevention, Phnom Penh, Cambodia
These authors contributed equally to this work
Citation style for this article: Chea N, Yi SD, Rith S, Seng H, Ieng V, Penh C, Mardy S, Laurent D, Richner B, Sok T, Ly S, Kitsutani P, Asgari N, Roces MC, Buchy P, Tarantola A. Two clustered cases of confirmed influenza A(H5N1) virus infection, Cambodia, 2011. Euro Surveill. 2014;19(25)
ii=20839. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20839
Date of submission: 09 October 2013
In February 2011, a mother and her child from Banteay Meanchey Province, Cambodia, were diagnosed, postmortem, with avian influenza A(H5N1) virus infection. A field investigation was conducted by teams from the Cambodian Ministry of Health, the World Health Organization and the Institut Pasteur in Cambodia. Nasopharyngeal, throat and serum specimens collected from 11 household or three neighbour contacts including two suspect cases tested negative by reverse transcriptase?polymerase chain reaction (RT-PCR) for A(H5N1). Follow-up sera from the 11 household contacts also tested negative for A(H5N1) antibodies. Twenty-six HCW who were exposed to the cases without taking adequate personal protective measures self-monitored and none developed symptoms within the two following weeks. An unknown number of passengers travelling with the cases on a minibus while they were symptomatic could not be traced but no clusters of severe respiratory illnesses were detected through the Cambodian surveillance systems in the two weeks after that.
The likely cause of the fatal infection in the mother and the child was common-source exposure in Preah Sdach District, Prey Veng Province. Human-to-human transmission of A(H5N1) virus was unlikely but genetic susceptibility is suspected. Clusters of A(H5N1) virus infection should be systematically investigated to rule out any human-to-human transmission.
more...
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20839
Surveillance and outbreak reports
TWO CLUSTERED CASES OF CONFIRMED INFLUENZA A(H5N1) VIRUS INFECTION, CAMBODIA, 2011
N Chea1, S D Yi2, S Rith3, H Seng2, V Ieng1, C Penh2, S Mardy1, D Laurent4, B Richner4, T Sok2, S Ly2, P Kitsutani5, N Asgari1, M C Roces1, P Buchy3,6, A Tarantola ()3,6
World Health Organization, Phnom Penh, Cambodia
Communicable Disease Control Department, Ministry of Health, Phnom Penh, Cambodia
Institut Pasteur du Cambodge, Phnom Penh, Cambodia
Jayavaraman VII Children Hospital, Kantha Bopha Foundation, Siem Reap City, Cambodia
United States? Centers for Disease Control and Prevention, Phnom Penh, Cambodia
These authors contributed equally to this work
Citation style for this article: Chea N, Yi SD, Rith S, Seng H, Ieng V, Penh C, Mardy S, Laurent D, Richner B, Sok T, Ly S, Kitsutani P, Asgari N, Roces MC, Buchy P, Tarantola A. Two clustered cases of confirmed influenza A(H5N1) virus infection, Cambodia, 2011. Euro Surveill. 2014;19(25)
ii=20839. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20839Date of submission: 09 October 2013
In February 2011, a mother and her child from Banteay Meanchey Province, Cambodia, were diagnosed, postmortem, with avian influenza A(H5N1) virus infection. A field investigation was conducted by teams from the Cambodian Ministry of Health, the World Health Organization and the Institut Pasteur in Cambodia. Nasopharyngeal, throat and serum specimens collected from 11 household or three neighbour contacts including two suspect cases tested negative by reverse transcriptase?polymerase chain reaction (RT-PCR) for A(H5N1). Follow-up sera from the 11 household contacts also tested negative for A(H5N1) antibodies. Twenty-six HCW who were exposed to the cases without taking adequate personal protective measures self-monitored and none developed symptoms within the two following weeks. An unknown number of passengers travelling with the cases on a minibus while they were symptomatic could not be traced but no clusters of severe respiratory illnesses were detected through the Cambodian surveillance systems in the two weeks after that.
The likely cause of the fatal infection in the mother and the child was common-source exposure in Preah Sdach District, Prey Veng Province. Human-to-human transmission of A(H5N1) virus was unlikely but genetic susceptibility is suspected. Clusters of A(H5N1) virus infection should be systematically investigated to rule out any human-to-human transmission.
more...
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20839