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Study links armadillos and leprosy in humans in the southern US

Shiloh

Editor, Senior Moderator
Source: http://www.eurekalert.org/pub_releases/2011-04/epfd-stf042211.php

Public release date: 27-Apr-2011

Contact: Michael Mitchell
michael.mitchell@epfl.ch
41-798-103-107
Ecole Polytechnique F?d?rale de Lausanne

Swiss-US team finds indigenous cases of leprosy in the Southern United States
Study confirms human contamination through contact with armadillos

Using advanced DNA analysis and extensive field work, an international research team has confirmed the link between leprosy infection in Americans and direct contact with armadillos. In a joint collaboration between the Global Health Institute at EPFL in Switzerland and Louisiana State University, clear evidence was found that a never-before-seen strain of Mycobacterium leprae has emerged in the Southern United States and that it is transmitted through contact with armadillos carrying the disease. The results will be published on April 28th in the New England Journal of Medicine.

There are only around 150 cases of leprosy in the United States each year. Most of these victims have worked abroad in areas in which leprosy is endemic, making it likely that they may have acquired the disease while outside the US. But, to the alarm of health authorities, a third of all patients infected appear to have contracted the disease locally. The hypothesis that the disease is transmitted though contact with armadillos?aside from humans, the only other known carriers of the leprosy-causing bacteria?was confirmed by fine-grained DNA analysis of both armadillo and human samples done at EPFL...

...###

"Probable Zoonotic Leprosy in the Southern United States," Authors: Richard W. Truman, Ph.D., Pushpendra Singh, Ph.D., Rahul Sharma, Ph.D., Philippe Busso, Jacques Rougemont, Ph.D., Alberto Paniz-Mondolfi, M.D., Adamandia Kapopoulou, M.S., Sylvain Brisse, Ph.D., David M. Scollard, M.D., Ph.D., Thomas P. Gillis, Ph.D., and Stewart T. Cole, Ph.D. New England Journal of Medicine, April 28, 2011.

Researcher Contact:

Pushpendra Singh, Ph.D.
Chair of Microbial Pathogenesis, EPFL
pushpendra.singh@epfl.ch
Cell: +41 76 242 30 84
 
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