tetano
Editor, Senior Moderator
Vaccine. 2014 Jan 13. pii: S0264-410X(13)01786-6. doi: 10.1016/j.vaccine.2013.12.043. [Epub ahead of print]
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses.
Gallorini S1, Taccone M2, Bonci A2, Nardelli F2, Casini D2, Bonificio A3, Kommareddy S3, Bertholet S2, O'Hagan DT3, Baudner BC2.
Author information
Abstract
Influenza is a vaccine-preventable disease that remains a major health problem world-wide. Needle and syringe are still the primary delivery devices, and injection of liquid vaccine into the muscle is still the primary route of immunization. Vaccines could be more convenient and effective if they were delivered by the mucosal route. Elicitation of systemic and mucosal innate and adaptive immune responses, such as pathogen neutralizing antibodies (including mucosal IgA at the site of pathogen entry) and CD4+ T-helper cells (especially the Th17 subset), have a critical role in vaccine-mediated protection. In the current study, a sublingual subunit influenza vaccine formulated with or without mucosal adjuvant was evaluated for systemic and mucosal immunogenicity and compared to intranasal and intramuscular vaccination. Sublingual administration of adjuvanted influenza vaccine elicited comparable antibody titers to those elicited by intramuscular immunization with conventional influenza vaccine. Furthermore, influenza-specific Th17 cells or neutralizing mucosal IgA were detected exclusively after mucosal immunization.
Copyright ? 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
Influenza, Mucosal IgA, Sublingual, Subunit-vaccine, Th17 response
PMID:
24434044
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24434044
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses.
Gallorini S1, Taccone M2, Bonci A2, Nardelli F2, Casini D2, Bonificio A3, Kommareddy S3, Bertholet S2, O'Hagan DT3, Baudner BC2.
Author information
Abstract
Influenza is a vaccine-preventable disease that remains a major health problem world-wide. Needle and syringe are still the primary delivery devices, and injection of liquid vaccine into the muscle is still the primary route of immunization. Vaccines could be more convenient and effective if they were delivered by the mucosal route. Elicitation of systemic and mucosal innate and adaptive immune responses, such as pathogen neutralizing antibodies (including mucosal IgA at the site of pathogen entry) and CD4+ T-helper cells (especially the Th17 subset), have a critical role in vaccine-mediated protection. In the current study, a sublingual subunit influenza vaccine formulated with or without mucosal adjuvant was evaluated for systemic and mucosal immunogenicity and compared to intranasal and intramuscular vaccination. Sublingual administration of adjuvanted influenza vaccine elicited comparable antibody titers to those elicited by intramuscular immunization with conventional influenza vaccine. Furthermore, influenza-specific Th17 cells or neutralizing mucosal IgA were detected exclusively after mucosal immunization.
Copyright ? 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
Influenza, Mucosal IgA, Sublingual, Subunit-vaccine, Th17 response
PMID:
24434044
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24434044