tetano
Editor, Senior Moderator
J Heart Lung Transplant. 2010 Jun 9. [Epub ahead of print]
Successful bilateral lung transplantation in a patient with end-stage lung disease and positive novel influenza virus (H1N1).
Al Aklabi MM, Weinkauf JG, Humar A, Ghorpade N.
Division of Cardiac Surgery, Heart and Lung Transplantation, Alberta, Canada.
Abstract
In 2009, a pandemic novel influenza virus (H1N1) outbreak was declared by the World Health Organization and resulted in significant worldwide illness. This report describes a 50-year-old male with end-stage lung disease secondary to alpha(1)-anti-trypsin deficiency and chronic obstructive pulmonary disease. He was admitted for potential bilateral lung transplantation when suitable organs became available. Incidentally, he was found to have some non-specific symptoms, including malaise and myalgias. These findings were attributed to killed-virus H1N1 vaccine given 48 hours earlier. However, as a safety measure, a nasopharyngeal swab was taken, and anti-viral therapy with oseltamivir (Tamiflu) was started empirically. He underwent bilateral lung transplantation on the same day of admission. In the immediate post-operative period his nasopharyngeal swab came back positive for H1N1 influenza virus. Then, post-operatively, two consecutive bronchoalveolar lavage samples from the transplanted lungs were found to be positive for H1N1 virus. He received three-weeks of antiviral treatment post-operatively and he had uneventful procedure with favorable outcome. Copyright ? 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PMID: 20538489 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20538489
Successful bilateral lung transplantation in a patient with end-stage lung disease and positive novel influenza virus (H1N1).
Al Aklabi MM, Weinkauf JG, Humar A, Ghorpade N.
Division of Cardiac Surgery, Heart and Lung Transplantation, Alberta, Canada.
Abstract
In 2009, a pandemic novel influenza virus (H1N1) outbreak was declared by the World Health Organization and resulted in significant worldwide illness. This report describes a 50-year-old male with end-stage lung disease secondary to alpha(1)-anti-trypsin deficiency and chronic obstructive pulmonary disease. He was admitted for potential bilateral lung transplantation when suitable organs became available. Incidentally, he was found to have some non-specific symptoms, including malaise and myalgias. These findings were attributed to killed-virus H1N1 vaccine given 48 hours earlier. However, as a safety measure, a nasopharyngeal swab was taken, and anti-viral therapy with oseltamivir (Tamiflu) was started empirically. He underwent bilateral lung transplantation on the same day of admission. In the immediate post-operative period his nasopharyngeal swab came back positive for H1N1 influenza virus. Then, post-operatively, two consecutive bronchoalveolar lavage samples from the transplanted lungs were found to be positive for H1N1 virus. He received three-weeks of antiviral treatment post-operatively and he had uneventful procedure with favorable outcome. Copyright ? 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PMID: 20538489 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20538489