tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2017 Aug 7;4(3)
fx145. doi: 10.1093/ofid/ofx145. eCollection 2017 Summer.
[h=1]Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review.[/h] Alsolami A[SUP]1[/SUP], Shiley K[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A case of influenza-associated acute necrotizing encephalitis (ANE) is described in an otherwise healthy adult. The patient was treated successfully with a combination of high-dose methylprednisolone and high-dose oseltamivir. The patient relapsed after discontinuing 150 mg twice daily oseltamivir but quickly improved and eventually recovered after reinitiation of high-dose oseltamivir for an additional 2 weeks. The clinical presentation, pathogenesis, and treatment of influenza-associated ANE is reviewed. The use of high-dose oseltamivir in combination with methylprednisolone may offer additional therapeutic benefit for this rare and poorly understood complication of influenza infection.
[h=4]KEYWORDS:[/h] acute necrotizing encephalitis; encephalitis; encephalopathy; influenza; oseltamivir
PMID: 28852683 PMCID: PMC5570039 DOI: 10.1093/ofid/ofx145
fx145. doi: 10.1093/ofid/ofx145. eCollection 2017 Summer.[h=1]Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review.[/h] Alsolami A[SUP]1[/SUP], Shiley K[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A case of influenza-associated acute necrotizing encephalitis (ANE) is described in an otherwise healthy adult. The patient was treated successfully with a combination of high-dose methylprednisolone and high-dose oseltamivir. The patient relapsed after discontinuing 150 mg twice daily oseltamivir but quickly improved and eventually recovered after reinitiation of high-dose oseltamivir for an additional 2 weeks. The clinical presentation, pathogenesis, and treatment of influenza-associated ANE is reviewed. The use of high-dose oseltamivir in combination with methylprednisolone may offer additional therapeutic benefit for this rare and poorly understood complication of influenza infection.
[h=4]KEYWORDS:[/h] acute necrotizing encephalitis; encephalitis; encephalopathy; influenza; oseltamivir
PMID: 28852683 PMCID: PMC5570039 DOI: 10.1093/ofid/ofx145