Summary of status of development and availability of A(H5N1) candidate vaccine viruses* and potency testing reagents (WHO, edited)

[Giuseppe]

[Source: World Health Organization, full PDF document: (LINK). Edited.]


Summary of status of development and availability of A(H5N1) candidate vaccine viruses* and potency testing reagents


* Antigenic and genetic analyses are performed by the WHO Collaborating Centres of the Global Influenza Surveillance and Response System.

National or Regional control authorities approve the composition and formulation of vaccines used in each country.


15 November 2011


Candidate vaccine viruses


Updated H5N1 nomenclature: http://www.who.int/influenza/gisrs_laboratory/h5n1_nomenclature/en/index.html


[Parent virus ? Clade - Candidate vaccine virus - Developing institute - Available from]

• A/Vietnam/1194/2004 - 1 - NIBRG-14 - NIBSC, UK - NIBSC, UK
• A/Vietnam/1203/2004 - 1 - SJRG-161052 - CDC, USA- ST. JUDE, USA-HKU, China - ST.JUDE; USA
• A/Cambodia/R0405050/2007 - 1.1 - NIBRG-88 - NIBSC, UK - NIBSC, UK
• A/duck/Hunan/795/2002 - 2.1 - SJRG-166614 - ST. JUDE, USA-HKU, China - ST.JUDE; USA
• *A/Indonesia/5/2005 - 2.1.3.2 - CDC-RG2 - CDC, USA - CDC, USA
• A/chicken/India/NIV33487/2006 - 2.2 - IBCDC-RG7 - NIV, India - CDC, USA - NIV, India - CDC, USA
• A/bar headed goose/Qinghai/1A/2005 - 2.2 - SJRG-163222 - ST. JUDE, USA - HKU, China - ST.JUDE, USA
• A/whooper swan /Mongolia/244/2005 - 2.2 - SJRG-163243 - ST. JUDE, USA - ST.JUDE, USA
• A/turkey/Turkey/1/2005 - 2.2.1 - NIBRG-23 - NIBSC, UK - NIBSC, UK
• A/Egypt/2321-NAMRU3/2007 - 2.2.1 - IDCDC-RG11 - CDC, USA - CDC, USA
• #A/Egypt/N03072/2010 - 2.2.1 - IDCDC-RG29 - CDC, USA - CDC, USA
• A/Egypt/3300-NAMRU3/2008 - 2.2.1.1 - IDCDC-RG13 - CDC, USA - CDC, USA
• A/common magpie/Hong Kong/5052/2007 - 2.3.2.1 - SJRG-166615 - ST. JUDE, USA - HKU, China - ST. JUDE, USA
• A/duck/Laos/3295/2006 - 2.3.4 - CBER-RG1 - CBER/FDA, USA - CBER/FDA, USA
• A/Anhui/1/2005 - 2.3.4 - IBCDC-RG6 - CDC, USA - CDC, USA
• A/Japanese white eye/HK/1038/2006 - 2.3.4 - SJRG-164281 - ST. JUDE, USA HKU, China - ST.JUDE, USA
• A/chicken/Hong Kong/AP156/2008-like - 2.3.4 - SJ-002 - ST. JUDE, USA - HKU, China - ST.JUDE, USA
• A/goose/Guiyang/337/2006 - 4 - SJRG-165396 - ST. JUDE, USA - HKU, China - ST.JUDE, USA
• A/chicken/Vietnam/NCVD-016/2008 - 7.1 - IDCDC-RG12 - CDC, USA - CDC, USA

*Availability updated
#A/Egypt /N03072/2010 is an A/Egypt/1394-NAMRU3/2007-like virus



Candidate vaccine viruses in preparation

[Parent virus - Clade - Candidate Vaccine Virus - Developing Institute - Available from]

• A/barn swallow/Hong Kong/D10-1161/2010-like - 2.3.2.1 - ST. JUDE, USA - HKU, China - Pending
• A/Hubei/1/2010 - 2.3.2.1 - CDC, USA - Pending
• A/chicken/Vietnam/NCVD-03/2008-like - 7.1 - CDC, USA - Pending

Viruses proposed by WHO for candidate vaccine virus preparation

[Parent virus - Clade - Developing Institute]

• A/chicken/Bangladesh/11rs1984-30/2011-like - 2.3.4.2 ? Pending

Institutes and contact details for candidate vaccine virus orders and other information:

• CBER/FDA: Centre for Biologics Evaluation and Research/ Food and Drug Administration, USA: Zhiping.ye@fda.hhs.gov
• NIBSC: National Institute for Biological Standards and Control ,UK :standards@nibsc.hpa.org.uk
• ST. JUDE: St. Jude Children's Research Hospital, USA: richard.webby@stjude.org
• NIV: National Institute of Virology, India: acm1750@rediffmail.com
• HKU: University of Hong Kong , China Hong Kong, SAR: malik@hkucc.hku.hk
• CDC: Centers for Disease Control and Prevention , Atlanta USA: rdonis@cdc.gov

Reference antigens (freeze dried)

[Starting materials: Parent virus ? CVV - Ref. Ag. Lot# ? Unitage (μgHA/ml) - Available from]

• A/Vietnam/1194/2004 - NIBRG-14 - 09/184 - 67 - NIBSC, UK
• A/turkey/Turkey/1/2005 - NIBRG-23 - 07/112 - 80 - NIBSC, UK
• A/Anhui/1/2005 - IBCDC-RG6 - 07/290 - 99 - NIBSC, UK
• A/Cambodia/R0405050/2007 - NIBRG-88 - 08/216 - TBA - NIBSC, UK
• A/Vietnam/1203/2004 - 161052 (SJCRH) - 50 - 152 - CBER/FDA, USA
• A/Indonesia/05/2005 - IBCDC-RG2 - 0904 - 77 - CBER/FDA, USA
• A/Bar-headed goose/Qinghai/1A/2005 - 163222 (SJCRH) - 63 - 69 - CBER/FDA, USA

Sheep antisera

[Purified HA from: Parent virus - Order Lot # - Available from]

• A/Anhui/1/2005
  • 07/338 - NIBSC, UK
  • 08/142 - NIBSC, UK
• A/Cambodia/R0405050/2007 - 08/210 - NIBSC, UK
• A/Hong Kong/489/97 - 98/666 - NIBSC, UK
• A/Vietnam/1203/2004 - S-124, S-125 - CBER/FDA, USA
• A/Indonesia/05/2005 - S-7854 - CBER/FDA, USA
• A/Bar-headed goose/Qinghai/1A/2005 - S-112SP - CBER/FDA, USA

The above-listed potency testing reagents for A(H5N1) vaccines have been developed with support from WHO CCs, ERLs and designated Influenza A(H5N1) developing institutes, and calibrated by the Essential Regulatory Laboratories (ERLs) that provide advice to WHO as part of the influenza vaccine virus selection and development process.

ERLs contact details for reagent orders and other information:

• CBER/FDA: Rajesh.Gupta@fda.hhs.gov
• NIBSC: standards@nibsc.hpa.org.uk

For general enquiries, please contact gisrs-whohq@who.int
For information of other type and subtype candidate vaccine viruses and potency testing reagents, please go to: http://www.who.int/influenza/vaccines/virus/en/



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