tetano
Editor, Senior Moderator
Support Care Cancer
. 2021 Mar 29.
doi: 10.1007/s00520-021-06149-1. Online ahead of print.
Prognostic factors in patients with advanced cancer and COVID-19: a cohort from the Palliative Care Unit of the Brazilian National Cancer Institute
Livia Costa de Oliveira[SUP] 1 [/SUP], Karla Santos da Costa Rosa[SUP] 2 [/SUP], Alessandra Zanei Borsatto[SUP] 2 [/SUP], Luciana Aparecida Faria de Oliveira[SUP] 2 [/SUP], Renata de Freitas[SUP] 2 [/SUP], Simone Garruth Dos Santos Machado Sampaio[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: To describe overall survival (OS) in 90 days and to evaluate the prognostic factors in patients with advanced cancer and COVID-19.
Methods: This is a retrospective cohort study carried out at the Palliative Care Unit of the Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 confirmed by Reverse Transcription Polymerase Chain Reaction were included. Kaplan-Meier's curves, log-rank test, and Cox regression were performed.
Results: Eighty-three inpatients were selected. The average age was 61.4 (?12.6) years, with a higher proportion of women (73.4%). The most prevalent tumor type was breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 [interquartile range (IQR): 6-70] days, and at the end of the follow-up period, 17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR): 2.03; 95% confidence interval (CI): 1.09-3.78], with lung tumors (HR: 17.50; 95% CI: 1.70-28.34), with lung metastasis (HR: 4.21; 95% CI: 2.17-8.15), and with chronic obstructive pulmonary disease (HR: 4.92; 95% CI: 1.01-24.69) had higher risk of death in 90 days.
Conclusion: The age of 60-74 years old, lung tumors (primary or metastases), and the presence of chronic obstructive pulmonary disease were considered independent prognostic factors in patients with advanced cancer and COVID-19.
Keywords: Advanced cancer; Coronavirus; Hospital mortality; Palliative care; Prognosis.
. 2021 Mar 29.
doi: 10.1007/s00520-021-06149-1. Online ahead of print.
Prognostic factors in patients with advanced cancer and COVID-19: a cohort from the Palliative Care Unit of the Brazilian National Cancer Institute
Livia Costa de Oliveira[SUP] 1 [/SUP], Karla Santos da Costa Rosa[SUP] 2 [/SUP], Alessandra Zanei Borsatto[SUP] 2 [/SUP], Luciana Aparecida Faria de Oliveira[SUP] 2 [/SUP], Renata de Freitas[SUP] 2 [/SUP], Simone Garruth Dos Santos Machado Sampaio[SUP] 2 [/SUP]
Affiliations
- PMID: 33779801
- DOI: 10.1007/s00520-021-06149-1
Abstract
Objective: To describe overall survival (OS) in 90 days and to evaluate the prognostic factors in patients with advanced cancer and COVID-19.
Methods: This is a retrospective cohort study carried out at the Palliative Care Unit of the Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 confirmed by Reverse Transcription Polymerase Chain Reaction were included. Kaplan-Meier's curves, log-rank test, and Cox regression were performed.
Results: Eighty-three inpatients were selected. The average age was 61.4 (?12.6) years, with a higher proportion of women (73.4%). The most prevalent tumor type was breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 [interquartile range (IQR): 6-70] days, and at the end of the follow-up period, 17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR): 2.03; 95% confidence interval (CI): 1.09-3.78], with lung tumors (HR: 17.50; 95% CI: 1.70-28.34), with lung metastasis (HR: 4.21; 95% CI: 2.17-8.15), and with chronic obstructive pulmonary disease (HR: 4.92; 95% CI: 1.01-24.69) had higher risk of death in 90 days.
Conclusion: The age of 60-74 years old, lung tumors (primary or metastases), and the presence of chronic obstructive pulmonary disease were considered independent prognostic factors in patients with advanced cancer and COVID-19.
Keywords: Advanced cancer; Coronavirus; Hospital mortality; Palliative care; Prognosis.