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Swine flu worse in Mexico than US, but why?

Re: Swine flu worse in Mexico than US, but why?

INFLUENZA A (H1N1) - WORLDWIDE (17)
***********************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Fri 8 May 2009
From: Marcel Jonges
<Marcel.Jonges@RIVM.NL>


Travel-associated influenza A (H1N1) with a virus containing a mutation in PB2
"Travel-associated influenza A (H1N1)" is pure propaganda (in HEADLINE). Promed continues to embarass scientific community with nonsense posts.
 
Re: Swine flu worse in Mexico than US, but why?

This is from CIDRAP, May 8:

WHO experts held a conference call yesterday with Mexican officials to discuss clinical findings in the patients who died from severe swine flu infections, Sylvie Briand, acting director of the WHO's Global Influenza Program, said today at a media briefing. Mexican health officials have identified two high-risk groups: previously healthy young people who deteriorated rapidly with acute pneumonia and people with chronic health conditions such as cardiovascular disease or tuberculosis. Briand said viral pneumonia has played a role in the deaths, but bacterial pneumonia has been less of a factor, unlike in other pandemics. Authorities have found that causes of death are typically respiratory failure or organ failure.
 
Re: Swine flu worse in Mexico than US, but why?

One of the Mexican isolates had two SNPs in PB2 , not seen in any other isolates...



There is evidence that the Mexican swine flu strain is NOT the same as the North American strain -- contrary to the pronouncement of Dr. Frank Plummer at the Canadian National Laboratory of Microbiology -- who held a press conference yesterday...


Regarding the genetic analysis of Mexican Swine Flu vs. Canadian Swine Flu -- There are SNPs on PA and PB2 , which are ONLY present in the Mexican strain -- a sequence released by Dr. Plummer's own laboratory! The fact that this difference was in his own data should bring into question the credibility of government health labs' ability and will to protect the public interest..


Suppose we use New York / Canada as the consensus strain. There are two unique polymorphisms found ONLY in Mexico (so far, anyway):



L275I on PA
N82S on PB2

mexicosnp3.png


mexicosnp2.png
 
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Re: Swine flu worse in Mexico than US, but why?

One of the Mexican isolates had two SNPs in PB2 , not seen in any other isolates...

That's interesting. In plain English does that mean just one patient?

Were other Mexican isolates the same as the N.American ones?
 
Re: Swine flu worse in Mexico than US, but why?

Yes, at least one isolate (patient) had this -- A/Mexico/InDRE4487/2009(H1N1). But curiously, this particular published sequence had no information on the patient, age, location, etc. The two SNPs on this strain are different from all other sequences around the world, and occur on the PA gene and the PB2 gene.
 
Re: Swine flu worse in Mexico than US, but why?

the mutations are not in another published Mexican virus
nor in a close Arizona virus.
So it's presumably just a variation which didn't spread
 
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