tetano
Editor, Senior Moderator
Emerg Infect Dis. 2017 Feb;23(2):241-251. doi: 10.3201/eid2302.161374.
[h=1]Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile.[/h] Bravo-Vasquez N, Karlsson EA, Jimenez-Bluhm P, Meliopoulos V, Kaplan B, Marvin S, Cortez V, Freiden P, Beck MA, Hamilton-West C, Schultz-Cherry S.
[h=3]Abstract[/h] Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested that antibody titers to the swine Chilean H1N2 virus were decreased in persons born after 1990. Further studies are needed to characterize the potential risk to humans, as well as the ecology of influenza in swine in South America.
[h=4]KEYWORDS:[/h] Chile; H1N1 pandemic strain; H1N2; South America; backyard farm; backyard production system; influenza; influenza A; swine influenza virus; transmission; viruses; zoonoses
PMID: 28098524 DOI: 10.3201/eid2302.161374
[PubMed - in process] Free full text
[h=1]Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile.[/h] Bravo-Vasquez N, Karlsson EA, Jimenez-Bluhm P, Meliopoulos V, Kaplan B, Marvin S, Cortez V, Freiden P, Beck MA, Hamilton-West C, Schultz-Cherry S.
[h=3]Abstract[/h] Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested that antibody titers to the swine Chilean H1N2 virus were decreased in persons born after 1990. Further studies are needed to characterize the potential risk to humans, as well as the ecology of influenza in swine in South America.
[h=4]KEYWORDS:[/h] Chile; H1N1 pandemic strain; H1N2; South America; backyard farm; backyard production system; influenza; influenza A; swine influenza virus; transmission; viruses; zoonoses
PMID: 28098524 DOI: 10.3201/eid2302.161374
[PubMed - in process] Free full text