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Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic
and Asymptomatic Influenza A Infection
Huang Zaas Rao Dobigeon Woolf Veldman Øien McClain Varkey Nicholson Carin Kings
Woods Ginsburg Hero
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002234
- interactions between hosts and viruses play a crucial role in determining the presence
and absence of symptoms [4].
- peak symptom time analysis reported in Zaas et al. [17],
- 17 healthy human volunteers aged 18 to 45 received intranasal inoculation
of A/Wisconsin/67/2005 (H3N2) and 9 of these subjects developed mild to severe symptoms
all subjects were healthy and tested negative for H3N2 influenza antibody at pre-inoculation time
None of the volunteers had been vaccinated for any influenza virus in the previous 3 years
All got oral oseltamivir 75 mg twice daily at day 6
- BLU factor (in blood) score shown in Figure 1A bears striking resemblance to the standardized clinical
symptom observation matrix in Figure 1B.
- recent study identified 66 and 87 human proteins that physically interact with H3N2/Udorn
and H1N1/A/PR/8/34 (PR8) viruses, respectively [25].
- Asx hosts induce a leukocyte response with
enhanced cellular protein biosynthesis.
- protective role of antioxidants SOD1 and SOK1
superoxide dismutase (SOD1)
serine/threonine kinase 25 (STK25 or SOK1)
- Asx infections account for 30–50% of seasonal flu cases [2],
- Asx and Sx displayed inoculation dosage-independent viral shedding
- rapid innate response rather than failed inoculation in Asx
- serum neutralizing antibody (nAb) titre were nearly identical in Asx and Sx on day 0 and day 7
- nAb titre increased over time in both Asx and Sx individuals
- no statistically significant dependence between disease outcome and inoculation dosage
- the amount of viral shedding from the site of infection independent of inoculation doses
- two seroconverted Asx subjects
- sustained upregulation of 35! ribosomal proteins in only Asx subjects
- increase of white blood cells in Asx subjects
- these Asx hosts appeared to be capable of mounting a more potent cell-mediated innate
immune response than the symptomatic subjects.
----------------------
comment by wbgrant about the possible role of vitamin D :
http://www.plosgenetics.org/annotat...notation/b761db38-b594-44b3-b608-1743595d6ab7
however he doesn't address the author's explanation and findings which doesn't
seem to involve vitamin D effects
their mention of antioxydants reminded me to antiviral effects of those in some natural remedies
---------------------
and Asymptomatic Influenza A Infection
Huang Zaas Rao Dobigeon Woolf Veldman Øien McClain Varkey Nicholson Carin Kings
Woods Ginsburg Hero
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002234
- interactions between hosts and viruses play a crucial role in determining the presence
and absence of symptoms [4].
- peak symptom time analysis reported in Zaas et al. [17],
- 17 healthy human volunteers aged 18 to 45 received intranasal inoculation
of A/Wisconsin/67/2005 (H3N2) and 9 of these subjects developed mild to severe symptoms
all subjects were healthy and tested negative for H3N2 influenza antibody at pre-inoculation time
None of the volunteers had been vaccinated for any influenza virus in the previous 3 years
All got oral oseltamivir 75 mg twice daily at day 6
- BLU factor (in blood) score shown in Figure 1A bears striking resemblance to the standardized clinical
symptom observation matrix in Figure 1B.
- recent study identified 66 and 87 human proteins that physically interact with H3N2/Udorn
and H1N1/A/PR/8/34 (PR8) viruses, respectively [25].
- Asx hosts induce a leukocyte response with
enhanced cellular protein biosynthesis.
- protective role of antioxidants SOD1 and SOK1
superoxide dismutase (SOD1)
serine/threonine kinase 25 (STK25 or SOK1)
- Asx infections account for 30–50% of seasonal flu cases [2],
- Asx and Sx displayed inoculation dosage-independent viral shedding
- rapid innate response rather than failed inoculation in Asx
- serum neutralizing antibody (nAb) titre were nearly identical in Asx and Sx on day 0 and day 7
- nAb titre increased over time in both Asx and Sx individuals
- no statistically significant dependence between disease outcome and inoculation dosage
- the amount of viral shedding from the site of infection independent of inoculation doses
- two seroconverted Asx subjects
- sustained upregulation of 35! ribosomal proteins in only Asx subjects
- increase of white blood cells in Asx subjects
- these Asx hosts appeared to be capable of mounting a more potent cell-mediated innate
immune response than the symptomatic subjects.
----------------------
comment by wbgrant about the possible role of vitamin D :
http://www.plosgenetics.org/annotat...notation/b761db38-b594-44b3-b608-1743595d6ab7
however he doesn't address the author's explanation and findings which doesn't
seem to involve vitamin D effects
their mention of antioxydants reminded me to antiviral effects of those in some natural remedies
---------------------