tetano
Editor, Senior Moderator
ACS Med Chem Lett. 2012 Oct 22;3(12):1065-9. doi: 10.1021/ml300279b. eCollection 2012.
Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.
Torres E1, Fern?ndez R1, Miquet S1, Font-Bardia M2, Vanderlinden E3, Naesens L3, V?zquez S1.
Author information
Abstract
The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.
KEYWORDS:
M2 channel; Ritter reaction; Wagner−Meerwein rearrangement; amantadine; influenza
PMID:
24900429
[PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/24900429
Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.
Torres E1, Fern?ndez R1, Miquet S1, Font-Bardia M2, Vanderlinden E3, Naesens L3, V?zquez S1.
Author information
Abstract
The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.
KEYWORDS:
M2 channel; Ritter reaction; Wagner−Meerwein rearrangement; amantadine; influenza
PMID:
24900429
[PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/24900429