Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents

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Arch Pharm (Weinheim). 2013 Nov 24. doi: 10.1002/ardp.201300260. [Epub ahead of print]
Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.
Elayadi H, Smietana M, Vasseur JJ, Balzarini J, Lazrek HB.
Source

Unit? de Chimie Biomol?culaire et M?dicinale, Laboratoire de Chimie Biomol?culaire Substances Naturelles et R?activit? (URAC 16), Faculty of Science Semlalia, Marrakech, Morocco.
Abstract

Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).

? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KEYWORDS:

1,2,3-Triazolyl nucleoside, Anti-influenza A (H3N2), Click reaction

PMID:
24272912
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24272912