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Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neu

tetano

tetano

Editor, Senior Moderator
Bioorg Med Chem Lett. 2014 Apr 18. pii: S0960-894X(14)00380-1. doi: 10.1016/j.bmcl.2014.04.032. [Epub ahead of print]
Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase.
Tollas S1, Bereczki I1, Borb?s A1, Batta G2, Vanderlinden E3, Naesens L4, Herczegh P5.
Author information
Abstract

In order to obtain self assembling, multivalent ligand for influenza virus hemagglutinin α-N-acetylneuraminyl-(2-6)-d-galactopyranose has been synthesized and bonded to a water soluble fullerene derivative using 1,3-dipolar cycloaddition click reaction. The aggregating amphiphilic compound did not inhibit the influenza virus hemagglutinin, but it proved to be an inhibitor of its neuraminidase with a 50% inhibitory concentration of 81μM.

Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:

Aggregation, Antiviral activity, Fullerene, Multivalent ligand, Sialic acid, Thiodisaccharide

PMID:
24767844
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24767844
 
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