tetano
Editor, Senior Moderator
Bioorg Khim. 2010 Nov-Dec;36(6):841-848.
[Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses.]
[Article in Russian]
Kazakova OB, Medvedeva NI, Baikova IP, Tolstikov GA, Lopatina TV, Yunusov MS, Zaprutko L.
Institute of Organic Chemistry Ufa Scientific Center, 450054, Ufa, pr. Oktyabrya 71, Russia. obf@anrb.ru.
Abstract
The synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. In studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-O-methoxycynnamoylbetulin shows high activity against influenza type A (H1N1) the selectivity index SI > 100. The high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain HPV-11) was detected, the selectivity index SI was 35.
PMID: 21317951 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21317951
[Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses.]
[Article in Russian]
Kazakova OB, Medvedeva NI, Baikova IP, Tolstikov GA, Lopatina TV, Yunusov MS, Zaprutko L.
Institute of Organic Chemistry Ufa Scientific Center, 450054, Ufa, pr. Oktyabrya 71, Russia. obf@anrb.ru.
Abstract
The synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. In studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-O-methoxycynnamoylbetulin shows high activity against influenza type A (H1N1) the selectivity index SI > 100. The high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain HPV-11) was detected, the selectivity index SI was 35.
PMID: 21317951 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21317951