tetano
Editor, Senior Moderator
Syst Rev
. 2024 Jul 19;13(1):189.
doi: 10.1186/s13643-024-02597-y. COVID-19 antibody responses in individuals with natural immunity and with vaccination-induced immunity: a systematic review and meta-analysis
Qiuying Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Lirui Jiao[SUP] #[/SUP][SUP] 2 [/SUP], Qiushi Chen[SUP] 3 [/SUP], Caroline A Bulstra[SUP] 4 5 6 [/SUP], Pascal Geldsetzer[SUP] 7 8 [/SUP], Tulio de Oliveira[SUP] 9 10 [/SUP], Juntao Yang[SUP] 1 [/SUP], Chen Wang[SUP] 11 [/SUP], Till Bärnighausen[SUP] #[/SUP][SUP] 4 [/SUP], Simiao Chen[SUP] #[/SUP][SUP] 12 13 [/SUP]
Affiliations
Background: The COVID-19 pandemic has caused a large mortality and morbidity burden globally. For individuals, a strong immune response is the most effective means to block SARS-CoV-2 infection. To inform clinical case management of COVID-19, development of improved vaccines, and public health policy, a better understanding of antibody response dynamics and duration following SARS-CoV-2 infection and after vaccination is imperatively needed.
Methods: We systematically analyzed antibody response rates in naturally infected COVID-19 patients and vaccinated individuals. Specifically, we searched all published and pre-published literature between 1 December 2019 and 31 July 2023 using MeSH terms and "all field" terms comprising "COVID-19" or "SARS-CoV-2," and "antibody response" or "immunity response" or "humoral immune." We included experimental and observational studies that provided antibody positivity rates following natural COVID-19 infection or vaccination. A total of 44 studies reporting antibody positivity rate changes over time were included.
Results: The meta-analysis showed that within the first week after COVID-19 symptom onset/diagnosis or vaccination, antibody response rates in vaccinated individuals were lower than those in infected patients (p < 0.01), but no significant difference was observed from the second week to the sixth month. IgG, IgA, and IgM positivity rates increased during the first 3 weeks; thereafter, IgG positivity rates were maintained at a relatively high level, while the IgM seroconversion rate dropped.
Conclusions: Antibody production following vaccination might not occur as quickly or strongly as after natural infection, and the IgM antibody response was less persistent than the IgG response.
Keywords: Antibody response; COVID-19; Meta-analysis.
. 2024 Jul 19;13(1):189.
doi: 10.1186/s13643-024-02597-y. COVID-19 antibody responses in individuals with natural immunity and with vaccination-induced immunity: a systematic review and meta-analysis
Qiuying Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Lirui Jiao[SUP] #[/SUP][SUP] 2 [/SUP], Qiushi Chen[SUP] 3 [/SUP], Caroline A Bulstra[SUP] 4 5 6 [/SUP], Pascal Geldsetzer[SUP] 7 8 [/SUP], Tulio de Oliveira[SUP] 9 10 [/SUP], Juntao Yang[SUP] 1 [/SUP], Chen Wang[SUP] 11 [/SUP], Till Bärnighausen[SUP] #[/SUP][SUP] 4 [/SUP], Simiao Chen[SUP] #[/SUP][SUP] 12 13 [/SUP]
Affiliations
- PMID: 39030630
- DOI: 10.1186/s13643-024-02597-y
Background: The COVID-19 pandemic has caused a large mortality and morbidity burden globally. For individuals, a strong immune response is the most effective means to block SARS-CoV-2 infection. To inform clinical case management of COVID-19, development of improved vaccines, and public health policy, a better understanding of antibody response dynamics and duration following SARS-CoV-2 infection and after vaccination is imperatively needed.
Methods: We systematically analyzed antibody response rates in naturally infected COVID-19 patients and vaccinated individuals. Specifically, we searched all published and pre-published literature between 1 December 2019 and 31 July 2023 using MeSH terms and "all field" terms comprising "COVID-19" or "SARS-CoV-2," and "antibody response" or "immunity response" or "humoral immune." We included experimental and observational studies that provided antibody positivity rates following natural COVID-19 infection or vaccination. A total of 44 studies reporting antibody positivity rate changes over time were included.
Results: The meta-analysis showed that within the first week after COVID-19 symptom onset/diagnosis or vaccination, antibody response rates in vaccinated individuals were lower than those in infected patients (p < 0.01), but no significant difference was observed from the second week to the sixth month. IgG, IgA, and IgM positivity rates increased during the first 3 weeks; thereafter, IgG positivity rates were maintained at a relatively high level, while the IgM seroconversion rate dropped.
Conclusions: Antibody production following vaccination might not occur as quickly or strongly as after natural infection, and the IgM antibody response was less persistent than the IgG response.
Keywords: Antibody response; COVID-19; Meta-analysis.