tetano
Editor, Senior Moderator
Expert Rev Vaccines. 2012 Feb;11(2):159-61.
Tailor-made cleavage site attenuates influenza B.
Saelens X.
Source
Department for Molecular Biomedical Research, VIB, 9000 Ghent, Belgium and Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium and Technologiepark 927, B-9052 Zwijnaarde (Ghent), Belgium. xavier.saelens@dmbr.vib-ugent.be.
Abstract
Evaluation of: Stech J, Garn H, Herwig A et al. Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine. J. Infect. Dis. 204(10), 1483-1490 (2011). Influenza B viruses contribute significantly to human influenza. The circulation of two antigenically divergent lineages of this virus can reduce the efficacy of licensed influenza vaccines. A novel live-attenuated influenza B vaccine candidate has been generated by creating a virus that strictly requires elastase activity for the accurate proteolytic maturation of its hemagglutinin. This mutant influenza B virus grows to high titers in vitro and is strongly attenuated in mice, yet it induces a robust protective immune response in this host. The findings on this tamed influenza B virus and its potential prospects are discussed.
PMID:
22309664
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22309664
Tailor-made cleavage site attenuates influenza B.
Saelens X.
Source
Department for Molecular Biomedical Research, VIB, 9000 Ghent, Belgium and Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium and Technologiepark 927, B-9052 Zwijnaarde (Ghent), Belgium. xavier.saelens@dmbr.vib-ugent.be.
Abstract
Evaluation of: Stech J, Garn H, Herwig A et al. Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine. J. Infect. Dis. 204(10), 1483-1490 (2011). Influenza B viruses contribute significantly to human influenza. The circulation of two antigenically divergent lineages of this virus can reduce the efficacy of licensed influenza vaccines. A novel live-attenuated influenza B vaccine candidate has been generated by creating a virus that strictly requires elastase activity for the accurate proteolytic maturation of its hemagglutinin. This mutant influenza B virus grows to high titers in vitro and is strongly attenuated in mice, yet it induces a robust protective immune response in this host. The findings on this tamed influenza B virus and its potential prospects are discussed.
PMID:
22309664
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22309664