tetano
Editor, Senior Moderator
Immunity. 2014 Apr 9. pii: S1074-7613(14)00109-5. doi: 10.1016/j.immuni.2014.02.013. [Epub ahead of print]
Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages.
Coulombe F1, Jaworska J1, Verway M1, Tzelepis F1, Massoud A1, Gillard J1, Wong G2, Kobinger G2, Xing Z3, Couture C4, Joubert P4, Fritz JH5, Powell WS1, Divangahi M6.
Author information
Abstract
Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to the demonstration of their inhibitory action on prostaglandins. Here, we show that during influenza A virus (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led to the inhibition of type I interferon (IFN) production and apoptosis in macrophages, thereby causing an increase in virus replication. This inhibitory role of PGE2 was not limited to innate immunity, because both antigen presentation and T cell mediated immunity were also suppressed. Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. These data demonstrate that the mPGES-1-PGE2 pathway is targeted by IAV to evade host type I IFN-dependent antiviral immunity. We propose that specific inhibition of PGE2 signaling might serve as a treatment for IAV.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
24726877
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24726877
Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages.
Coulombe F1, Jaworska J1, Verway M1, Tzelepis F1, Massoud A1, Gillard J1, Wong G2, Kobinger G2, Xing Z3, Couture C4, Joubert P4, Fritz JH5, Powell WS1, Divangahi M6.
Author information
Abstract
Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to the demonstration of their inhibitory action on prostaglandins. Here, we show that during influenza A virus (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led to the inhibition of type I interferon (IFN) production and apoptosis in macrophages, thereby causing an increase in virus replication. This inhibitory role of PGE2 was not limited to innate immunity, because both antigen presentation and T cell mediated immunity were also suppressed. Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. These data demonstrate that the mPGES-1-PGE2 pathway is targeted by IAV to evade host type I IFN-dependent antiviral immunity. We propose that specific inhibition of PGE2 signaling might serve as a treatment for IAV.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
24726877
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24726877