tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2019 Oct 13. doi: 10.1111/irv.12692. [Epub ahead of print] [h=1]The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics.[/h]
Chong CY[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Yung CF[SUP]1,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Gan C[SUP]5[/SUP], Thio ST[SUP]1[/SUP], Tan NW[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Tee NW[SUP]2,[/SUP][SUP]6[/SUP], Lin C[SUP]7[/SUP], Lin RT[SUP]2,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Thoon KC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Infectious Diseases, Department of Paediatrics, KK Women's and Children's Hospital, Singapore. 2 Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3 Duke-NUS Medical School, Singapore. 4 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. 5 Singhealth Residency Programme, Singapore General Hospital, Singapore. 6 Department of Laboratory Medicine, National University Hospital, Singapore. 7 National Public Health Laboratory, Ministry of Health, Singapore.
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] In tropical Singapore, influenza occurs all year-round. This study of influenza-confirmed hospitalized pediatric patients compared clinical characteristics and complications by age-group and differences between influenza A and B.
[h=4]METHODS:[/h] This was a retrospective study of pediatric inpatients from January 2013 to December 2014. Patients were grouped into: <6 months, 6 months to <5 years, 5- to <10-year and ≥10 years. Complications were classified into neurologic, pulmonary, and other. We also calculated the incidence of hospitalized influenza cases per 100 000 age-related population.
[h=4]RESULTS:[/h] There were a total of 1272 patients with a median age of 37 months. The highest hospitalization rates were in the <6 months age-group. Majority (75.2%) had no comorbidity; 25.6% had complications: neurologic 11.9%, pulmonary 9.6%, other 4.1%. Patients with other complications were older, male, and had the highest influenza B rates and the longest length of stay. Influenza A comprised 76.9% of cases and had higher complication rates especially neurologic, compared to influenza B. Influenza B patients were older and were more likely to develop other complications. The 6-month to <5-year-age-group had the highest complication rate (30.6%), especially neurologic. However, ≥10 years old had the highest other complications, ICU/ high-dependency admissions and influenza B Victoria rates.
[h=4]CONCLUSIONS:[/h] Infants <6 months had the highest hospitalization rates for influenza. The 6-month to <5-year-age-group had the highest complication rate especially neurologic. Influenza A patients were younger, had higher seizure rates and complications compared to influenza B.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] complications; disease burden; hospitalizations; influenza; pediatric
PMID: 31608598 DOI: 10.1111/irv.12692
Chong CY[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Yung CF[SUP]1,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Gan C[SUP]5[/SUP], Thio ST[SUP]1[/SUP], Tan NW[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Tee NW[SUP]2,[/SUP][SUP]6[/SUP], Lin C[SUP]7[/SUP], Lin RT[SUP]2,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Thoon KC[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Infectious Diseases, Department of Paediatrics, KK Women's and Children's Hospital, Singapore. 2 Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3 Duke-NUS Medical School, Singapore. 4 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. 5 Singhealth Residency Programme, Singapore General Hospital, Singapore. 6 Department of Laboratory Medicine, National University Hospital, Singapore. 7 National Public Health Laboratory, Ministry of Health, Singapore.
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] In tropical Singapore, influenza occurs all year-round. This study of influenza-confirmed hospitalized pediatric patients compared clinical characteristics and complications by age-group and differences between influenza A and B.
[h=4]METHODS:[/h] This was a retrospective study of pediatric inpatients from January 2013 to December 2014. Patients were grouped into: <6 months, 6 months to <5 years, 5- to <10-year and ≥10 years. Complications were classified into neurologic, pulmonary, and other. We also calculated the incidence of hospitalized influenza cases per 100 000 age-related population.
[h=4]RESULTS:[/h] There were a total of 1272 patients with a median age of 37 months. The highest hospitalization rates were in the <6 months age-group. Majority (75.2%) had no comorbidity; 25.6% had complications: neurologic 11.9%, pulmonary 9.6%, other 4.1%. Patients with other complications were older, male, and had the highest influenza B rates and the longest length of stay. Influenza A comprised 76.9% of cases and had higher complication rates especially neurologic, compared to influenza B. Influenza B patients were older and were more likely to develop other complications. The 6-month to <5-year-age-group had the highest complication rate (30.6%), especially neurologic. However, ≥10 years old had the highest other complications, ICU/ high-dependency admissions and influenza B Victoria rates.
[h=4]CONCLUSIONS:[/h] Infants <6 months had the highest hospitalization rates for influenza. The 6-month to <5-year-age-group had the highest complication rate especially neurologic. Influenza A patients were younger, had higher seizure rates and complications compared to influenza B.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] complications; disease burden; hospitalizations; influenza; pediatric
PMID: 31608598 DOI: 10.1111/irv.12692