tetano
Editor, Senior Moderator
Elife. 2015 Jan 16;4. doi: 10.7554/eLife.05055. [Epub ahead of print]
[h=1]The contrasting phylodynamics of human influenza B viruses.[/h] Vijaykrishna D[SUP]1[/SUP], Holmes EC[SUP]2[/SUP], Joseph U[SUP]1[/SUP], Fourment M[SUP]2[/SUP], Su YC[SUP]1[/SUP], Halpin R[SUP]3[/SUP], Lee RT[SUP]4[/SUP], Deng YM[SUP]5[/SUP], Gunalan V[SUP]4[/SUP], Lin X[SUP]3[/SUP], Stockwell TB[SUP]3[/SUP], Fedorova NB[SUP]3[/SUP], Zhou B[SUP]3[/SUP], Spirason N[SUP]5[/SUP], K?hnert D[SUP]6[/SUP], Boskova V[SUP]7[/SUP], Stadler T[SUP]8[/SUP], Costa AM[SUP]9[/SUP], Dwyer DE[SUP]10[/SUP], Huang QS[SUP]11[/SUP], Jennings LC[SUP]12[/SUP], Rawlinson W[SUP]13[/SUP], Sullivan SG[SUP]5[/SUP], Hurt AC[SUP]5[/SUP], Maurer-Stroh S[SUP]4[/SUP], Wentworth DE[SUP]3[/SUP], Smith GJ[SUP]1[/SUP], Barr I[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
[h=4]KEYWORDS:[/h] antigenic drift; epidemiology; evolution; evolutionary biology; genomics; human; infectious disease; influenza virus; microbiology; viruses
PMID: 25594904 [PubMed - as supplied by publisher] Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25594904
[h=1]The contrasting phylodynamics of human influenza B viruses.[/h] Vijaykrishna D[SUP]1[/SUP], Holmes EC[SUP]2[/SUP], Joseph U[SUP]1[/SUP], Fourment M[SUP]2[/SUP], Su YC[SUP]1[/SUP], Halpin R[SUP]3[/SUP], Lee RT[SUP]4[/SUP], Deng YM[SUP]5[/SUP], Gunalan V[SUP]4[/SUP], Lin X[SUP]3[/SUP], Stockwell TB[SUP]3[/SUP], Fedorova NB[SUP]3[/SUP], Zhou B[SUP]3[/SUP], Spirason N[SUP]5[/SUP], K?hnert D[SUP]6[/SUP], Boskova V[SUP]7[/SUP], Stadler T[SUP]8[/SUP], Costa AM[SUP]9[/SUP], Dwyer DE[SUP]10[/SUP], Huang QS[SUP]11[/SUP], Jennings LC[SUP]12[/SUP], Rawlinson W[SUP]13[/SUP], Sullivan SG[SUP]5[/SUP], Hurt AC[SUP]5[/SUP], Maurer-Stroh S[SUP]4[/SUP], Wentworth DE[SUP]3[/SUP], Smith GJ[SUP]1[/SUP], Barr I[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
[h=4]KEYWORDS:[/h] antigenic drift; epidemiology; evolution; evolutionary biology; genomics; human; infectious disease; influenza virus; microbiology; viruses
PMID: 25594904 [PubMed - as supplied by publisher] Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25594904